Life Extension News^™

by Durk Pearson and Sandy Shaw

• Shrinking Future Options During a Period of Economic Decline: Can Money Buy Happiness?
• Centenarians Have Preserved Immune Functions But a Lower Expression of Genes Inducing Inflammation
• Lift Weights, Eat Mustard, Build Muscles?
• Inhibition of Inducible Nitric Oxide Synthase Reverses Tobacco-Smoke Induced Emphysema in Mice
• Oops! Weather Forecasting the Old-Fashioned Way

• Iron Deficiency in Obese Mexican Women and Children—Association with Inflammation But Not Iron Intake
• Immune Gene Upregulation in Aging Mouse Brain Parallels Declines in Cognition, Motivation, and Locomotion
• The Brain Glucose Transporter GLUT-1 Also Transports Dehydroascorbic Acid Into the Brain Where It is Reduced To Ascorbic Acid
• Looking for a Few Good Laughs
• Americans Getting Inadequate Amounts of Some Vitamins and Minerals
• Is Your Current Body Weight a Threat To Your Health
• Why Are Rates of Diabetes Higher in Americans As Compared to Brits of Similar Weight
• Sorry—No Chuckles or Giggles here ... But You Might Like to Know Why the Value of the Dollar Keeps Falling ...
• Inflammatory Exposure via Stimulants of Toll-Like Receptors in Foods: Possible Effects on Risk of Disease and Life Expectancy
• Remarkable New Findings: When Fish Oils Meet Cannabis Receptors: A Result is Powerful Protection of the Brain Against Neuroinfla

• Central Planning As Intelligent Design Why Doesn’t It Work?
• Hair Care: Do Products That Claim to Repair Split Ends Really Repair Split Ends?
• The Triage Theory of Aging: Why Modest Inadequacy of Vitamins or Minerals May Increase Diseases of Aging Later
• Gut Microbiota (Resident Microbial Community in the GI Tract) Affect Host Use of Selenium
• Mechanisms Underlying the Adverse Effects of HDL from Patients with Coronary Artery Disease As Compared to HDL from Healthy Indi
• (1) Can Congress Force You to Buy Broccoli? (2) Is That a Hard Question?

• Niacin Inhibits the Progression of Atherosclerosis New Mechanisms Help Explain Its Protective Effects
• Selenium Protects Against Calcification in Blood Vessels by Preventing Vascular Smooth Muscle Cells From Acting Like Bone
• The 2010 Dietary Guidelines The Latest Dietary Advice From the Government is No Help At All Good Advice: Fire the USDA and the H
• Pain Relief Starts in the Brain Blockade of TNF-alpha (Tumor Necrosis Factor-alpha) Inhibits the Brain’s Response to Pain
• There May Be a Lot More Polyphenols in the Circulation Than Just Those Found in the Plasma

• Comparison of Efficacy of Turmeric and Curcumin in Immunological Measures and Gene Regulation
• Dietary Intake of Docosahexaenoic Acid (DHA) Provides More Neuroprotection in Transgenic Mice
• Post-Operative Cognitive Decline Associated with a Cytokine Cascade Triggered by Tumor Necrosis-Factor-Alpha
• Correlated Genotypes in Friendship Networks

• Mirthful Laughter Improves Vascular Function
• Restricting Food Intake to the Active (Dark) Phase Prevents Body Mass Gain in Mice
• The Unfortunate Result of Poorly Designed Clinical Trials without Adequate Explanation of Findings
• Anti-aging and Rejuvenating Effects of Quercetin in Aging and Senescent Fibroblasts
• Quercetin, N-acetylcysteine Prevent Muscle Disuse Atrophy
• Disease Risk Alleles Do Not Compromise Human Longevity in Genome Study
• Low Dose Resveratrol Partially Mimics Caloric Restriction, Retards Some Aspects of Aging
• DHEA Replacement Therapy in Older Women Results in Significant Improvements in Spine BMD
• Upper Body Subcutaneous (sc) Fat Cells Differently Affected by Overeating Than Lower Body sc Fat Cells
• Delay in Administering Hormone Replacement Therapy in Postmenopausal Women Results in Loss of Estrogen Protection: Possible Prev

• Inflammation as an Indicator of Sensitivity to Social Rejection
• Sodium Selenite Increases Mean and Maximum Lifespan of Banana Fruitfly
• Protection by Trehalose Against Mutant Protein Causing a Neurodegenerative Disease
• Theabrownin May Be the Main Bioactive Molecule in Pu-erh Tea
• Kidney Function Declines with age and AGEs and Is A Major Source of Mortality
• Omega-3 Fatty Acids and Inflammation, Insulin-Sensitivity, Fatty Liver
• Two Recipes from Sandy’s Kitchen

• Sleep Apnea
• White Blood Cell Count and Risk of Mortality
• Patients on a Low Salt Diet Have Increased Mortality
• If You Have a Heart Attack, Be Sure To Do This While on Your Way to the Hospital
• Reducing Uncertainty in Decisionmaking By Hand Washing
• Diabetes, Insulin Resistance
• Sell Off Some of the Nature Preserves and Protected Areas to Invest In More Cost-Effective Conservation

• Alzheimer’s disease: Fish oil and EGCG act synergistically to inhibit cerebral amyloid beta deposits
• Predicting future cognitive decline: Markers help predict future cognitive decline in individuals without dementia
• Alzheimer’s disease: ApoE4 found to be carried by VLDL and is possibly converted by VLDL into a more pathogenic form
• Chronic obstructive pulmonary disease: Decreased histone deacetylase activity results in resistance to antiinflammatory effect
• Prostate Cancer, Breast Cancer, and Alzheimer’s disease: More on the effects of carbonyl compounds
• Weight control, diabetes: Inhibition of starch digestion by black tea
• Fat reduction: Consumption of acetic acid (vinegar) suppresses body fat accumulation in mice
• Good News! We win yet another First Amendment suit against the FDA!!
• Glioblastoma: Experimental treatment that may never be approved by the FDA
• Psychobiochemistry: Testosterone decreases trust in human social relationships

• Orange Juice and Obesity, Insulin Resistance, and Atherosclerosis
• Anti-Aging Supplements: Plant Extracts That Inhibit Elastase and Collagenase
• Cardioprotection and Neuroprotection Against Ischemia-Reperfusion Injury: New Use for a Very Old Drug
• Chronic Activation of NF-kappaB, the Master Regulator of Inflammation, Induces Senescence
• Cardioprotection, Possible Life Extension: Inhibitors of mTOR Revisited: Resveratrol
• Another Autophagy Inducer: Trehalose
• Kidney Injury and Recovery: Serotonin Receptor Stimulation Increases Mitochondrial Biogenesis
• Emerging Medicine: Angiogenesis Inhibitor: What Does Athlete’s Foot Have to Do with Angiogenesis?

• Life Extension by Inhibiting Growth
• Adipocyte Size Predicts Risk of Type 2 Diabetes in Women
• Melatonin Preserves Longevity Protein SIRT1 Expression in the Hippocampus and Cognitive Function of Total Sleep-Deprived Rats
• Knee Arthritis Relief

• How You Can Have Your [Chocolate] Cake And Eat Its Flavanols, Too
• Consumption of Cocoa Powder Reduces Inflammatory Biomarkers in Patients at High Risk of Cardiovascular Disease
• Remarkable Stability of Cocoa Contents During Long Storage
• New Research Focuses on Important Protective Protein Released by Fat Cells: Adiponectin
• Green Tea Catechins Against Influenza A Virus
• Get Your Prestigious Award Today!
• L-Arginine Supplementation Protects Against Ischemia/Reperfusion Injury as Occurs in Heart Attacks and Strokes
• You Can Increase Your Paraoxonase 1 (PON 1) Gene Expression to Protect Against Cardiovascular Disease and HDL and LDL Oxidation
• Critique: "Using Neural Measures of Economic Value to Solve the Public Goods Free-Rider Problem"
• Advance in Understanding of Autoimmune Disease: T-Cell Self-Tolerance Requires Sirt1

• More on Tea (Camellia sinensis): Cholesterol and Triglyceride Regulation, and Neuroprotection
• Low choline levels associated with high anxiety levels in human study
• More on curcumin, a major constituent of turmeric
• Curcumin as a maintenance treatment for ulcerative colitis
• Higher levels of vitamin D associated with improvements in certain aspects of cognitive function
• Hesperidin protects against myocardial ischemia/reperfusion induced arrhythmias and apoptosis
• Inflammation and insulin resistance resulting from CLA (conjugated linoleic acid) supplementation in mice
• New management needed at Yale University Press
• Surprise discovery: BHT is a natural antioxidant
• Monosodium glutamate, a natural flavor enhancer
• The effects of glutamate on energy homeostasis
• Special investment report: Swiss bank advises clients to get out of U.S. stocks, bonds
• Co-Association Between Insulin Sensitivity and Measures of Liver Function
• Factors Influencing Cholesterol Homeostasis in Subjects at High Risk of Developing Cardiovascular Disease
• Increasing HDL Levels with Anthocyanins

• Fighting for the First Amendment and Supplements
• n-3 Fatty Acids:Natural “Doping” for Enhanced Endurance. Migrating Birds Improve Physical Fitness by Eating!
• We Highly Recommend for Improved Health and Possibly Even Longer Life: Supplementation with Turmeric
• Vitamin D Induces Increased Levels of Cystatin D, a Candidate Tumor Suppressor Gene in Colon Cancer
• High Triglycerides, Diabetes: Black Tea Suppresses Postprandial Hypertriacylglycerolemia
• Emphysema, Pulmonary Fibrosis, and Lung Cancer: Quercetin and Curcumin Protect Against Nitric Oxide Modification of Lung Anti-Pr

• Sandy’s Wonderful Potato Salad
• Chronic Stress: Curcumin Protection in Chronically Stressed Rats
• Sleep Deprivation: Curcumin Protects Against Behavioral Alterations and Oxidative Damage in 72 Hour Sleep-Deprived Mice
• Long-Term Administration of Green Tea Catechins Prevents Age-Related Declines in Cognition in Mice
• New Pathways of Influenza Virus Replication and Possible Inhibition by Natural Products
• Could the French Paradox and the Benefits of the Mediterranean Diet Be Partly Due to Activation of the Niacin Receptor?
• The Niacin Flush: Could It Signal a Heart Protective Pathway?
• Quack “Economics” in a Major Science Journal
• Is a Preference for Inflation Hard-Wired in Humans?

• "Organized Science" Going to the Dogs (or, as in This Case, to the Frogs)
• Climate Change Treaty Negotiations: Oil Exporting Nations Want Bailout
• Effects of Potassium on Blood Pressure via Reduction of Endothelial "Stiffness" and Increased NO Release
• Protective Effect of the Inhibition of the Renin-Angiotensin System of Aging
• Hydrogen Sulfide as a Mediator of Erection via Corpus Cavernosum Smooth-Muscle Relaxation
• Leptin, a Hormone Important in Satiety and Food Intake, Decreases After Meals Cooked at High Temperatures
• Upregulation of Aldose Reductase During Foam Cell Formation: Possible Link Among Diabetes, Hyperlipidemia, and Atherosclerosis
• A Secret for Successful Negotiation: Fish
• When Money Dies

• Vitamin C Treatment Reduces C-Reactive Protein but Only in Those Who Have High CRP
• Short-Term Oral L-Arginine Improves Fasting Vascular Endothelial Function
• Phenolic Compounds Rutin and o-Coumaric Acid Ameliorate Obesity Induced by High Fat Diet in Rats
• Acute Treatment of Stroke with Red Wine Polyphenols
• Superoxide Radicals, NO, and cGMP: Links Between Erectile Dysfunction and Cardiovascular Disease
• DNA Damage, Repair, and Aging
• Indole-3-Carbinol, a Potent Tumor Suppressor Example: Human Breast Cancer
• Elastase Inhibitors Could Be a Useful Therapy for COPD
• Liar, Liar, Pants on Fire or Where Global Warming is Really Coming From

• Happy New Year! Live Long & Prosper!!
• L-Arginine Prevents Metabolic Effects of High Glucose in Diabetic Mice
• Fatty Acid Synthase as a Target for Antiviral Therapy
• Cysteine Decreases Expression of Genes Involved in Liver Cell Fatty Acid Synthesis
• Slowing Aging by De-AGEing: Western Diets Contain High Levels of Fat and Also of AGEs
• Beta-alanine Supplementation Augments Muscle Carnosine Content and Improves Muscular Performance
• Resveratrol, at Concentrations Attainable by Moderate Wine Consumption, Increases NO Production
• Absorption of Sulforaphane in Humans Higher After Consuming Raw As Opposed to Cooked Broccoli
• Fed Refuses to Disclose Recipients of $2 Trillion
• GlaxoSmithKline and Allies Petition the FDA to Disallow Weight Loss Claims for Dietary Supplements

• The Most Endangered Species Is Sanity
• Cold in Them Thar Hills
• New Blades Added to the Swiss Army Knife of Preventive Medicine: Aspirin
• Myeloperoxidase (MPO), a Risk Factor in Atherogenesis; Protective Dietary Substances
• Oleic Acid Responsible for the Blood Pressure-Reducing Effect of Olive Oil
• White Wine Has Cardioprotective Effects by Activating a Cell Survival Pathway, Including the Longevity-Associated Gene FOXO3a
• You’d Be Depressed Too If You Were Suspended by Your Tail—Relief of Depression with SSRIs and 5-HTP
• Scrumptious and Good-For-You Cranberry Sauce for the Holidays

• Wisdom from The Myth of the Rational Voter by Bryan Caplan
• The Logic of Business in a Heavily Regulated Economy, Then and Now
• AGE Inhibitors: Potential Therapy for Prevention and/or Treatment of Dementia
• Protection by Spices Against Cell Damage Caused by Peroxynitrite
• Tinnitus May Be Caused by Peroxynitrite No, Oh No!
• Caloric Restriction (CR) in Skeletal Muscle of Rhesus Monkeys: Effects of CR May Be Species-Specific
• Varying Effects of Calorie Restriction in Two Strains of Mice
• Another Dogma Bites the Dust! Adult Humans Do Have Brown Fat

• Earth to Loony Bin: The Triffids Were Offended
• An Exercise Device for People Who Don’t Exercise
• No Oil, No Problem . . . for the Nazis
• Reducing Risk of Breast Cancer Recurrence by Lowering Insulin Levels
• Don’t Look Behind You—Something Might Be Catching Up
• Inflammatory Responses to Eating Mitigated by Certain Nutrients
• Local Cooling, Not Warming
• Effects of Various Types of Fats on Heart Cells
• U.S. Supreme Court Rules on Right to Freedom from Unreasonable Searches and Seizures
• Libertarian, Like Me: The Search for the Libertarian Brain

• The Saturated Fat Palmitate Induces Insulin Resistance, Which Is Reversed by the Monounsaturated Fat Oleate
• Natural Metabolites of Dietary Quercetin Target and Protect Macrophages from Becoming Foam Cells
• Astaxanthin Promotes Fat Metabolism, Rather Than Glucose Metabolism, During Exercise Improving Endurance
• Seasonal Flu Shots May Protect Against Bird Flu
• Ghrelin: A Mere Hormonal Appetite Stimulant or a Possible Anti-Aging Molecule

• A Year of Global Cooling
• Prevention of HDL Oxidation that Is Associated with Loss of HDL Atheroprotection
• Motif Maps from Microarrays Reveal Enforcement of Aging by Continual NF-kappaB Activity
• Improving Quality Control in Raw Materials for Dietary Supplements Imported from China
• Medicinal Mushrooms at Your Supermarket Improve Immune Function
• Activation of Autophagy for Neuroprotection: Lithium Induces Autophagy, Delays Amyotrophic Lateral Sclerosis

• Enhancing Learning and Memory and Neurogenesis with Tryptophan-Induced Serotonin Increase
• It’s Never Too Late! Improved Mental and Physical Performance in Centenarians Treated with L-Carnitine
• Nutrients That Inhibit Age-Associated Reduction in Telomere Length
• Hydrogen Sulfide Is Responsible for the Vasoactivity of Garlic
• Vitamin E Reduces Oxidative Stress and Inflammation in Patients with Coronary Artery Disease
• Predicting the Outcome of Elections from Rapid Impressions of Candidates’ Faces
• Shadow Government Statistics: Tells You Much More About the Economy Than What the Government Tells You
• Good News for Moderate Drinkers of Red Wine
• Bad News for the DEA: More Evidence for the Cancer-Inhibitory Effects of Cannabinoids

• Durk & Sandy’s Anti-Aging Regimen
• Importance of PGC-1alpha in Maintaining Skeletal Muscle Function and Integrity
• FDA’s Body Count Mounts as the Agency Increases Its Suppression of New Medical Therapies
• A Possible Mechanism Contributing to Loss of Estrogen Cardioprotection in Late Postmenopausal Women
• If You Find Yourself in a Hole, Stop Digging

• Recovery of "Lost" Memories Possible with Enriched Environment or Butyrate Treatment
• Advanced Glycation End Products (AGEs) and Life Extension
• Low-AGE Cooking With a Tajine

• Mortality in Antioxidant Trials
• Fish Oils Approved by FDA for Reducing Triglycerides—Prescription Required
• Losing Weight and Improving Your Health with a Carbohydrate-Restricted Diet
• Comparison of Atkins, Zone, Ornish, and LEARN Diets in Overweight Premenopausal Women
• Dietary Factors and Adiponectin, a Fat-Derived Peptide that Improves Insulin Sensitivity: Moderate Alcohol Strikes Again
• Suppression of Fatty Acid Synthase in Breast Cancer Cells by Tea and Tea Polyphenols
• Combinations of Biomarkers Predictive of Later-Life Mortality
• Cocoa Reduces LDL Oxidative Susceptibility and Increases HDL-Cholesterol

• Additional Benefits of Caloric Restriction When Only Carbohydrate Calories Are Restricted
• Glucose Ingestion Induces Inflammation; Insulin Is Anti-Inflammatory
• Treatment with L-Arginine and L-Citrulline with Antioxidants Prevents High-Glucose-Induced Cellular Senescence
• Indigestible Carbohydrates Contribute to Improved Glycemic Response at Next Meal
• Possible Health Benefit of Lactose Intolerance: Protection Against Colorectal Cancer
• Bhhhrrrzzzt! The Sound Heard Round the World
• Safe at Last
• Qualified Health Claim That Tea May Reduce Risk of Cardiovascular Disease Rejected by FDA
• Recipe for Barley, Currant, and Herb Pilaf

• Special Report on Climate Change
• Blueberry Polyphenols Increase Lifespan and Thermotolerance in C. elegans
• Beneficial Effects of the Laminar Shear Stress Response Mimicked by Procyanidin-Rich Grape Seed Extract and Hawthorn
• Farmed Atlantic Salmon Highly Enriched in EPA and DHA
• C-Reactive Protein May Induce Leptin Resistance
• Testosterone Inhibits Early Atherogenesis in Male Mice
• Cognition-Enhancing Drugs May Work Exactly the Same in Rats as Environmental Enrichment
• Interleukin-1beta, a Mediator of Inflammation and Possibly Aging
• Changes in White Blood Cell Counts May Predict Increased Risk of Mortality in Older Women

• Modulation of Glucocorticoid Action by Vitamin D on Aging Hippocampal Cells
• Potential Antiaging Effects of Vitamin D3 Protection Against Neurotoxic Agents
• Glucocorticoids Induce Muscle Wasting: Could Vitamin D Provide Protection?
• Vitamin D Dosage and Cancer Chemoprevention
• Vitamin D Supplementation as a Possible Treatment for Heart Failure
• Effects of Acetic Acid (Vinegar) on Glycemic and Insulinemic Response to Food: Inhibitory Effects on Digestive and Other Enzymes
• Not Just for the Heart! Changes Mediated by Inflammation in the Aging Brain Reversed by Treatment with EPA
• A Low-Enough LDL May Reduce Cardiovascular Risk to Nearly Nonexistent
• When Pigs Have Fins: The New Health Snacks—Pork Skins and Bacon?
• Pomegranate Juice Improves Myocardial Perfusion in Patients with Coronary Heart Disease
• Broker-Importer Sues FDA for Blocking Ephedra Importation
• Moderate Alcohol Consumption Increases Neurogenesis in the Adult Mouse

• Pomegranate Juice Reduces Cholesterol Synthesis in Macrophages in Cell Culture
• Pomegranate Juice Inhibits Serum Angiotensin-Converting Enzyme (ACE) Activity and Reduces Systolic Blood Pressure
• L-Arginine Therapy in Acute Myocardial Infarction: Why the Negative Results? Could It Have Been Prevented?
• Decreasing Superoxide Radicals with Zingerone
• Prevention of Obesity by Anthocyanins
• Betaine Suppresses Inflammation During Aging: Possible Antiaging Effect
• FDA UPDATE: Our Suit Against the FDA, Case No. 05-1937 Before the United States Court of Appeals for the Fourth Circuit
• Health Freedom Protection Act, H.R. 4282, Introduced in Congress

• Warrantless Searches of Doctor's Offices
• Blueberry Gingerbread Cake for Health and Great Taste
• Aspirin Reduces Endothelial Cell Senescence
• Mild Heat Stress Protects Muscle Mass During Immobilization in Rats
• Effects of Caloric Restriction May Be Partly Due to Enhanced Expression of Endothelial Nitric Oxide Synthase
• Arginine and C-Reactive Protein
• Docosahexaenoic Acid Increases Phosphatidylserine in Neuronal Membranes
• Fast Access of Some Grape Pigments to the Brain
• Phase 2: The Next Step in Controlling Inflammation in Arthritis and Atherosclerosis
• Codex Alimentarius Commission: Latest U.S. Draft Position on the Scientific Basis of Health Claims

• Restless Legs: The Iron Connection
• Tocopherol Radical Regeneration by Antioxidants
• Arginine Improves Endothelial Function in Healthy Individuals Older Than 70 Years
• Arginine and Protective Ischemic Preconditioning
• Cholinergic Agonists Improve Survival in Experimental Sepsis: Link to Arthritis
• Urinary Tract Infections: Nicotinic Acid Prevents Candida Adherence
• More on Glycogen Synthase Kinase-3, Inhibited by Lithium: Alzheimer’s, Neurotoxicity, and Cellular Senescence
• Serotonin Transporter Found in B-Cell Malignancies: Inhibition of Cancer Growth by Inhibiting Transporter
• Search Studies Show Airline Baggage Inspections a Waste of Time and Resources

• FLASH! Court Strikes Ephedra Ban
• Reducing C-Reactive Protein by Increasing Dietary Fiber
• Vitamin D in Prostate Cancer Patients with Increasing PSA Levels after Treatment
• Healthcare Systems Compared
• Increasing Homicide Rates and Linoleic Acid Consumption in Five Western Countries, 1961–2000
• p53: The Tradeoff Between Cancer Protection and Longevity
• Cancer Now Leading Cause of Death Except in the Very Elderly
• Cholinesterase Inhibitors: New Findings/New Benefits
• Slowing the Digestion of Carbohydrates for Better Blood Sugar Control and Possibly Longer Life
• Viagra Works by Inhibiting Phosphodiesterase 5
• Subsidizing Ants

• Omega-3 Fatty Acids and Coronary Heart Disease Health Claim
• New X Prize: This One for Extending Lifespan!
• FDA Evaluation of Drugs Is Flawed, a Threat to the Public Health
• More on the Failure of Antioxidant Trials in the Prevention of Heart Attacks
• Possible Induction of Terminal Differentiation of Breast Cancer and Prostate Cancer through PPARgamma
• Estrogen Upregulates Production of Prostacyclin through COX-2
• Arginine Protects Against NSAID-Induced Gastrointestinal Toxicity
• Inactivation of COX-1 by Red Wine
• Risk of Heart Attack and Stroke after Acute Infection or Vaccination
• Anti-Inflammatory, Antisepsis Effects of Glycine
• Risk of Heart Attack and Exposure to Traffic
• Green Tea Polyphenols as Acetylcholinesterase Inhibitors for Memory Improvement
• The Cholinergic Anti-Inflammatory Pathway
• USDA Ban on Ranchers Testing Their Cattle for BSE Is a Violation of the First Amendment

• The FDA and Your Right to a Jury Trial
• Tryptophan and the Response to Selective Serotonin Reuptake Inhibitors (SSRIs)
• Possible Antiatherosclerotic Effects of Hot Tubs
• High-Dose Alpha-Lipoic Acid Has Antiobesity Effects in Rats
• Disaggregating Toxic Protein Clumps
• HDL: Not Always “Good” Cholesterol
• Proinflammatory Cytokine Tumor Necrosis Factor-Alpha
• Reforming the Food, Drug, and Cosmetic Act

• Do Food Ads Promote Childhood Obesity?
• Good News for Medical Marijuana Patients
• Mechanism Discovered for Protective Effects of Cardiac Preconditioning
• Why Antioxidants in Large Randomized Trials Haven’t Shown Clear Benefits
• Connecting Alzheimer’s, Cardiovascular Disease, Parkinson’s Disease, and Type 2 Diabetes

• Inflammation After Eating a Mixed Meal: Eating May Be Hazardous to Your Health
• Prolactin: Sex and Immune Activation
• Loss of Muscle Mass with Aging: Interleukin-6 and Tumor Necrosis Factor-alpha
• Lycopene Inhibits Mineral Resorption from Bone
• Curcumin May Be Effective in Treating Cystic Fibrosis
• FDA Continues Its Murderous Rampage and Still Violates the First Amendment

• The Supreme Court, the FDA, and the First Amendment
• The Arginine Metabolic Pathways: Nitric Oxide Synthase and Arginase
• Red Wine Increases Expression of Human Endothelial Nitric Oxide Synthase
• High-Protein Diet May Increase Thermogenesis Compared to High-Carbohydrate Diet
• The Federal Death Administration Strikes Again: Drug Standards Applied to a Food
• Fat and Happy? Tryptophan Concentrations Reduced in Obesity
• Angiogenesis Inhibitors May Control Fat Tissue - New Blood Vessels Support Fat Growth
• Winning the War of All Against All - Searching for Lonerville

• Once Upon a Time . . .
• Life-Extending Sirtuins Activated by Resveratrol—Living Longer Through Red Wine?
• Centenarians in Japan
• FDA Update
• Lycopene May Not Provide All the Benefits of Tomatoes in Preventing Prostate Cancer
• Super-Delicious Tomato Recipe: Tomato-Lentil Salad
• Second Opinions Available from Major Hospitals
• Serum Insulin Concentrations are Lower in Daily Drinkers Compared with Abstainers
• Reversal of Cognitive Aging in Old Mice
• Thiol Antioxidants Reduce Bone Loss in Estrogen-Deficient Female Mice

• If Only It Worked When the Government Stole Your Cattle . . .
• Aspirin to the Rescue
• Ketone Bodies in Energy, Neuroprotection, . . .
• Coming Soon! To Your Kitchen from Ours!
• Curcumin in Phase I Clinical Trial Prevention of Cancer
• Xanthine Oxidase and Endothelial Dysfunction
• Xanthine Oxidase Mediates Cytokine-Induced Bone Resorption
• Xanthine Oxidase Inhibition by Flavonoids
• Quercetin and Kaempferol Inhibit in Vitro Osteoclastic Bone Resorption
• When Shopping for High-Polyphenol Cocoa, All Cocoas Are Not Alike
• Ecology and Bias in Scientific Media
• Ain't FDA Regulations Fun?
• Reforming the FDA
• Bioengineering Healthier Corn

• Tragedy of the Commons — NOT - Aug. 2003
• Caloric Restriction Does Not Increase the Lifespan of All Breeds of Mice - Aug. 2003
• Price Competition - Aug. 2003
• Phytoestrogens - Aug. 2003
• Epigallocatechin Gallate - Aug. 2003
• Rutin May Be Essential - Aug. 2003
• Amyloid Polypeptide - Aug. 2003
• Xanthine Oxidase and Muscle Damage in Strenuous Exercise - Aug. 2003
• Clitoris NO—Arginine Yes - Aug. 2003
• Book Review: Libertarian Science Fiction, The Excalibur Alternative, by David Weber - Aug. 2003
• Preventing Falls with Vitamin D and Calcium - Aug. 2003

• The Other War Heats Up: FDA Proposes Good Manufacturing Practices for Dietary Supplements - June 2003
• Durk & Sandy Say No: EPA Deciding Whether It Can Regulate the Puddle in Your Backyard as Waters of the United States - June 2003
• Tetrahydrobiopterin: Ubiquitous Metabolite - June 2003
• Sleep Duration and Body Temperature - June 2003
• Protection by Quercetin Against Cooking Oil Fume-Induced Lung Cancer in Taiwanese Women
• Preparing for the Next Appearance of Spanish Flu
• Air Pollution and Cardiovascular Episodes - June 2003
• At Home in the EU - June 2003
• Children with Cerebral Malaria

• FDA: Next Steps - Apr. 2003
• Free Radical Signaling and Antioxidant Protection - Apr. 2003
• Inhibition of Platelet-Derived Growth Factor Beta by Red Wine May Help Explain the “French Paradox” - Apr. 2003
• Red Wine Increases the Expression of Human Endothelial Nitric Oxide Synthase - Apr. 2003
• Lycopene Interferes with Cell Progression - Apr. 2003
• Lycopene May Be Useful in the Treatment of Prostate and Breast Cancer - Apr. 2003
• Diacylglycerol: New Cooking/Salad Oil - Apr. 2003
• Canada Allows Health Claims - Apr. 2003
• Homocysteine Upregulates 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase - Apr. 2003
• Moderate Beer Consumption - Apr. 2003
• SPECIAL SUPPLEMENT - Apr. 2003
• Speed Limit on Consciousness - Apr. 2003

• FDA Folds - The First Amendment Wins After 8 Years of Battle - Feb. 2003
• Garlic and Scallion Lovers, Rejoice! - Feb. 2003
• Tea Enhances Insulin Activity
• Why Antioxidants Do Not Necessarily Prevent Aging Due to Free Radicals - Feb. 2003
• Neuroprotection, IGF-1, and Alzheimer's Disease - Feb. 2003
• Well, at Least They're Safe - Feb. 2003

• Noradrenaline Metabolite a Powerful Antioxidant - Jan. 2003
• Folic Acid Against Cardiovascular Disease - Jan. 2003
• Isomer of Conjugated Linoleic Acid (CLA) - Jan. 2003
• Why We Take Cysteine Rather Than N-Acetylcysteine - Jan. 2003
• More Global Warming - Jan. 2003

• Preventing Cancer, Atherosclerosis, and Obesity Through Antiangiogenesis

• Durk Pearson & Sandy Shaw ® Life Extension News™, Vol. 5, No. 1

• Durk Pearson & Sandy Shaw ® Life Extension News™ - Special Supplement, Nov. 2001

• Durk Pearson & Sandy Shaw ® Life Extension News™, Vol. 4, No. 6

• Durk Pearson & Sandy Shaw ® Life Extension News™, Vol. 4, No. 5

• Durk Pearson & Sandy Shaw ® Life Extension News™, Vol. 4, No. 4

• Durk Pearson & Sandy Shaw ® Life Extension News™, Vol. 4, No. 3

• Durk Pearson & Sandy Shaw ® Life Extension News™, Vol. 4, No. 2b

• Durk Pearson & Sandy Shaw ® Life Extension News™, Vol. 4, No. 2a

• Durk Pearson & Sandy Shaw ® Life Extension News™, Vol. 4, No. 1

• Durk Pearson & Sandy Shaw ® Life Extension News™, Vol. 3, No. 5

• Durk Pearson & Sandy Shaw ® Life Extension News™, Vol. 3, No. 4

• Durk Pearson & Sandy Shaw ® Life Extension News™, Vol. 3, No. 3

• Durk Pearson & Sandy Shaw ® Life Extension News™, Vol. 3, No. 2

• Durk Pearson & Sandy Shaw ® Life Extension News™, Vol. 3, No. 1

• Durk Pearson & Sandy Shaw ® Life Extension News™, Vol. 2, No. 7

• Low-dose L-Arginine Improves Insulin Sensitivity
• Warm Feet Promote Rapid Onset of Sleep
• Omega-3 Fatty Acids in Manic Depression

• Index of Files and Description of Contents
• Codex
• Public Comments to FDA on Proposed Good Manufacturing Practices
• Before the Food and Drug Administration, Rockville, MD
• Arbitrary and Capricious FDA Concealment of Adverse Effect Data
• Specific Proposal for a Constitutional Acceptable Label
• Before the Food and Drug Administration, Rockville, MD
• Before the Food and Drug Administration, Rockville, MD
• Comments of Durk Pearson & Sandy Shaw and People for the Constitution
• Comparison of Food Safety to Nutrient Supplement Safety
• Durk Pearson & Sandy Shaw ® Life Extension News™, Vol. 2, No. 2
• Before the Federal Deposit Insurance Corporation, Washington, D.C.