Exacerbation of Bowel Disorders?

Q Is it possible, or has it been reported, that Bye-Lori II can exacerbate Crohn’s disease or other inflammatory bowel disorders?

Linda, Dallas

A We have had no reports of this occurring. Crohn’s disease is a chronic inflammatory bowel disease that most commonly affects the lower gastrointestinal tract, but it can occur anywhere in that tract, from stem to stern. Bye-Lori II, which contains the natural herb mastic, is known for its ability to eradicate the ulcer-causing bacterium Helicobacter pylori. This bacterium can not only cause stomach and intestinal ulcers, it can also lead to stomach cancer if left untreated for too long. Taking Bye-Lori II to help reverse the conditions that cause dyspepsia, gastritis, or ulcers—or even to help prevent stomach cancer—may be a sensible idea. Nevertheless, Helicobacter pylori infection is infrequent in Crohn’s disease.

The two ingredients in Boswell ReliefBoswellia and Curcuma extracts—have both been found to be helpful for inflammatory disorders, such as Crohn’s disease and others that affect the bowel.1-6 This product might be more appropriate for your condition.

Bear in mind that either of these natural products may, in some susceptible individuals, further irritate the already inflamed tissue characteristic of inflammatory bowel diseases, such as Crohn’s. It has been found that some people may even become sensitized to a generally innocuous ingredient, such as gelatin. So please proceed with caution, and work closely with your medical practitioner if you decide to take either or both of these products.

  1. Aggarwal BB, Shishodia S. Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann NY Acad Sci 2004 Dec;1030:434-41.
  2. Kiela PR, Midura AJ, Kuscuoglu N, Jolad SD, Solyom AM, Besselsen DG, Timmermann BN, Ghishan FK. The effects of Boswellia serrata in mouse models of chemically induced colitis. Am J Physiol Gastrointest Liver Physiol 2004 Nov 11 [online preprint].
  3. Srinivasan P, Libbus B. Mining MEDLINE for implicit links between dietary substances and diseases. Bioinformatics 2004 Aug 4;20 Suppl 1:I290-6.
  4. Ma TY, Iwamoto GK, Hoa NT, Akotia V, Pedram A, Boivin MA, Said HM. TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappaB activation. Am J Physiol Gastrointest Liver Physiol 2004 Mar;286(3):G367-76.
  5. Ammon HP. Boswellic acids (components of frankincense) as the active principle in treatment of chronic inflammatory diseases. Wien Med Wochenschr 2002;152(15-16):373-8.
  6. Gerhardt H, Seifert F, Buvari P, Vogelsang H, Repges R. Therapy of active Crohn disease with Boswellia serrata extract H 15. Z Gastroenterol 2001 Jan;39(1):11-7.

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