Protection from Aluminum

Q Is there any truth to the claim that excessive aluminum in our bodies can cause Alzheimer’s disease? If this is true, what Durk & Sandy product(s) can I take to prevent the buildup of aluminum in my body to help prevent Alzheimer’s?

CHRIS, Yorba Linda, CA

A The question of a causal relationship between aluminum and Alzheimer’s remains controversial, but there is evidence of a correlation between high levels of aluminum in certain areas of the brain and Alzheimer’s disease (AD).1 Although the cause of AD is not known, brain tissue of AD victims shows evidence of improper regulation or increased levels of aluminum, along with several other metals, creating a pro-oxidative environment. In experimental animals, aluminum causes the accumulation of amyloid-beta, a protein that constitutes the bulk of the senile plaque in AD brains.

In a study by researchers at the University of Barcelona, deferoxamine (DFOA) and citric, malic, and succinic acids were all found to be effective as chelating agents.2 When mice were given toxic doses of aluminum nitrate intraperitoneally, treatment with these four agents significantly increased the excretion of aluminum and reduced its concentration in various organs and tissues, with citric acid being the most effective.

In two other studies by the same research group, malic and succinic acids were found to be more effective than DFOA in increasing survival rates in mice,3 and they were found to be more effective than DFOA in removing four different types of aluminum from the spleen and liver of rats and mice.4

Durk & Sandy’s InnerPower contains significant amounts of malic and citric acids, organic fruit acids that have been found to decrease aluminum buildup in a variety of tissues. And their nutritional supplement that contains galantamine, lithium and other ingredients also contains a form of vitamin E (d-alpha-tocopheryl succinate) that is derived from succinic acid.

References

  1. Kawahara M. Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases. J Alzheimers Dis 2005 Nov;8(2): 171-82.
  2. Domingo JL, Gomez M, Llobet JM, Corbella J. Citric, malic and succinic acids as possible alternatives to deferoxamine in aluminum toxicity. J Toxicol Clin Toxicol 1988;26(1-2):67-79.
  3. Domingo JL, Gomez M, Llobet JM, Corbella J. Comparative effects of several chelating agents on the toxicity, distribution and excretion of aluminium. Hum Toxicol 1988 May;7(3):259-62.
  4. Llobet JM, Domingo JL, Gomez M, Tomas JM, Corbella J. Acute toxicity studies of aluminium compounds: antidotal efficacy of several chelating agents. Pharmacol Toxicol 1987 Apr;60(4):280-3.

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