The Durk Pearson & Sandy Shaw®
Life Extension NewsTM
Volume 11 No.
1 • January 2008
Bad News for the DEA: More Evidence for the Cancer-Inhibitory Effects of Cannabinoids
Matrix metalloproteinases are gelatinases that are importantly involved in the invasion of cancer cells. One of the important natural regulators of matrix metalloproteinases (MMPs) is TIMP, tissue inhibitors of MMPs. Researchers treated human cervical cancer (HeLa) cells with cannabinoids, an analog of the endogenous cannabinoid anandamide, as well as with Δ-tetrahydrocannabinol (THC), a constituent of cannabis; the cells were also exposed to the presence or absence of antagonists to cannabinoid receptors CB1 or CB2 or other receptors. At the lowest concentration tested, THC (0.01 μM) caused a decrease in invasion that was accompanied by an increase in the expression of TIMP-1. Pretreatment of cells with antagonists of CB11 or CB2 reversed the stimulation of TIMP-1 expression and the suppression of cell invasion.
The authors concluded, “Increased expression of TIMP-1 mediates an anti-invasive effect of cannabinoids. Cannabinoids may therefore offer a therapeutic option in the treatment of highly invasive cancers.”
Now, if only the cannabinoids could offer a therapeutic option for inhibiting highly invasive federal agencies like the DEA, EPA, and FDA.
- Ramer and Hinz. Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1. J Natl Cancer Inst 100:59-69 (2008).