The Durk Pearson & Sandy Shaw®
Life Extension NewsTM
Volume 12 No.
4 • August 2009
Vitamin D Induces Increased Levels of Cystatin D, a Candidate Tumor Suppressor Gene in Colon Cancer
While we are discussing cystatin (see
article above), it is interesting to note that cystatin D is a member of the cystatin superfamily of endogenous inhibitors of endosomal/lysosomal cysteine proteases. This particular cystatin may be a tumor suppressor, as it is an endogenous inhibitor of cysteine cathepsins that have been proposed to be major players in tumor progression as they are proteases that break down matrix components and adhesion proteins. A new paper reports that cystatin D RNA expression is increased by vitamin D (1alpha, 25(OH)2D3) treatment in colon cancer cells, which inhibits proliferation, invasiveness, migration and increases cell adhesiveness.
- Alvarez-Diaz et al. Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells. J Clin Invest 119(8):2343-58 (2009).