The Durk Pearson & Sandy Shaw®
Life Extension NewsTM
Volume 12 No. 5 • October 2009


Higher Levels of Vitamin D Associated With
Improvements in Certain Aspects of Cognitive
Function in Middle-aged and Older European Men

A new paper1 reports on the association between Vitamin D and cognition in 3,369 men aged 40–79 years from eight centers enrolled in the European Male Ageing Study. Tests for different aspects of cognition were included. There was no significant difference between those with high levels of 25(OH)D and those with lower levels except in the DSST test. The DSST test is described in the paper as a “subtest adopted from the Wechsler Adult Intelligence Scales and provides a reliable measure of psychomotor speed and visual scanning. Participants were asked to make as many correct symbol-for-digit substitutions as possible within a 1 minute period.”

The authors conclude: “Although we were unable to specifically explain this observation [the significant association between 25(OH)D levels and DSST scores], the DSST appears robust . . . .” However, note that the association between 25(OH)D and DSST score was only significant among the older men, that is, those aged 60–69 and 70–79.

  1. Lee et al. Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men. J Neurol Neurosurg Psychiatry 80:722-9 (2009).

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