The Durk Pearson & Sandy Shaw®
Life Extension NewsTM
Volume 12 No. 5 • October 2009

Inflammation and Insulin Resistance Resulting
from CLA (Conjugated Linoleic Acid)
Supplementation in Mice Attenuated by Resveratrol

We use CLA only at a low dose for its anti-carcinogenic properties because at the higher doses needed for anti-obesity effects, CLA has been reported to cause inflammation, insulin resistance, and endoplasmic reticulum stress in mice, humans and cell cultures of adipocytes.1 The authors of a new paper1 hypothesized that resveratrol, a known anti-inflammatory and antioxidant molecule, would attenuate the inflammation and insulin resistance caused by 10,12 CLA in human adipocytes (fat cells). The researchers used 50 µM resveratrol in human adipocytes cultured with 10,12 CLA and found that at this dose resveratrol prevented inflammation and attenuated the activation of ERK1/2 and induction of the genes for the inflammatory cytokines IL-6, IL-8, and IL-1beta within 12 hours. Resveratrol also blocked 10,12 CLA induction of the inflammatory prostaglandin pathway (PLA2, cyclooxygenase-2 (COX-2), and PGF2alpha).

The authors report: “Indeed, 10,12 CLA treated cultures co-supplemented with 50 µM RSV [resveratrol] had higher levels of insulin-stimulated glucose uptake, compared with cultures treated with 10,12 CLA alone. Consistent with these data, RSV blocked 10,12 CLA induction of SOCS-3, a protein that causes insulin resistance through serine phosphorylation of IRS-1.”

The only downside of these beneficial effects of resveratrol on CLA supplementation was that resveratrol attenuated some of the desired anti-obesity effects of CLA; “RSV co-supplementation attenuated delipidation and suppression of FA [fatty acid] uptake by 10,12 CLA.”

Nevertheless, if you are going to be using CLA at doses high enough for anti-obesity effects and want to avoid the adverse effects of CLA, we would suggest you also take resveratrol along with it. We get our daily resveratrol from dietary sources (mostly from the 1 or 2 glasses of red wine we drink per day) as well as from MealMate™, our weight maintenance help formulation (two capsules provides 40 mg of resveratrol).

  1. Kennedy et al. Conjugated linoleic acid-mediated inflammation and insulin resistance in human adipocytes are attenuated by resveratrol. J Lipid Res 50:225-32 (2009).

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