The Durk Pearson & Sandy Shaw®
Life Extension NewsTM
Volume 12 No. 5 • October 2009


The Effects of Glutamate on Energy Homeostasis

Another paper1 reported on the effects of glutamate consumption on various aspects of energy homeostasis. The researchers reported that chronic, ad lib ingestion of a palatable solution of monosodium L-glutamate (1% wt:vol) by rats “has also been found to reduce weight gain, fat deposition, and plasma leptin concentrations compared with rats that ingest water alone.” There was no difference in food intake. The authors1 suggest that these effects may be mediated by the vagal nerve signaling from the gut to the brain. As they explain, “[s]timulation of these [L-glutamate] receptors [in gut epithelial cells] by luminal L-glutamate activates vagal afferent nerve fibers and subsequently parts of the brain targeted directly or indirectly by these vagal inputs [e.g., the cerebral cortex, basal ganglia, limbic system, and hypothalamus].” In addition, the chronic, elective ingestion of a palatable solution of monosodium L-glutamate (MSG) by rats has been found to reduce the development of obesity, fat deposition, and elevated plasma leptin concentrations through an enhancement of energy expenditure.

The natural flavor molecules in Ineffable Essence can add a lot to the taste of meals containing foodstuffs that normally contain significant amounts of them, such as meats, dairy products, eggs, and vegetables. It won’t make awful food taste good (though it won’t make it worse), but it can make make good food taste great.

  1. Kondoh et al. Activation of the gut-brain axis by dietary glutamate and physiological significance in energy homeostasis. Am J Clin Nutr 90(Suppl.):832S-7S (2009).

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