The Durk Pearson & Sandy Shaw®
Life Extension NewsTM
Volume 12 No. 6 • October 2009


Green Tea Catechins Against Influenza A Virus

More research continues to be published on antiviral effects of tea catechins. In a new paper,1 researchers report that green tea catechins inhibit Influenza A viral endonuclease, an enzyme that is essential for the influenza virus to propagate.1 Tested catechins with a galloyl group (EGCG, epigallocatechin gallate, and ECG, epicatechin gallate) had inhibitory activity, while catechins such as EGC, EC (without galloyl group), and GA (galloyl group only) showed weaker or no inhibition activity compared to the catechins with a galloyl group. The researchers also found that the galloyl group of EGCG attaches to an active pocket of the endonuclease domain of influenza A virus RNA dependent RNA polymerase.

As explained in this paper, much is being learned about how the particular locations of galloyl groups and of hydroxyl groups in tea catechins allow these natural molecules to intervene with specificity in many different aspects of body biochemistry. This understanding is part of a new field called combinatorial chemistry, leading to new, less toxic medical treatments. Now all we need is a new, less toxic FDA to get out of the way.

We include 1.33 grams of green tea extract in the maximum suggested daily dose of our V-Shield.™ Of this, 90% are polyphenols, with EGCG representing 50% of the polyphenols.

  1. Kuzuhara et al. Green tea catechins inhibit the endonuclease activity of influenza A virus RNA polymerase. PLoS Currents Influenza 2009 Oct. 13:RRN1052.

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