Curcumin


Curcumin Improves Insulin Resistance in Rats

Curcumin (one of the active compounds in turmeric) has been reported to lower plasma lipids and glucose in diabetic rats, and to decrease body weight in obese rats, which may partly be due to increased fatty acid oxidation and utilization in skeletal muscle.

Those are the findings of a recent study conducted at Harbin Medical University, Harbin, China, where diabetic rats (induced by a high-fat diet plus streptozotocin) were fed a diet containing curcumin at 50, 150, or 250 mg/kg of body weight for 7 weeks.1 Curcumin was found to decrease plasma lipids and glucose in a dose-dependant fashion, and the dose 150 mg/kg of body weight seemed adequate to produce a significant effect.

Furthermore, curcumin supplementation reduced glucose and insulin tolerance. The researchers thought that curcumin improves muscular insulin resistance by increasing oxidation of fatty acid and glucose, which is partly mediated through the LKB1-AMPK pathway.

Reference

  1. Na LX, Zhang YL, Li Y, Liu LY, Li R, Kong T, Sun CH. Curcumin improves insulin resistance in skeletal muscle of rats. Nutr Metab Cardiovasc Dis 2010 Mar 12. [Epub ahead of print]

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