Can FoldRight™ Be Taken With Food?

Q Should FoldRight be taken on an empty stomach, and if not, can it be taken with a protein powder without limiting absorption and effectiveness?

Kenneth, West Kingston, RI

A It is not necessary to take FoldRight on an empty stomach, and it can be taken with a protein powder without loss of absorption or effectiveness. However, if you’re taking a phenylalanine plus cofactors supplement, such as a BLAST family product, for best effects you want to take that on an empty stomach because other large amino acids in the diet (or from a protein powder) can interfere with the passage of phenylalanine across the blood brain barrier. FoldRight does not contain any of the “large, neutral” side chains, so it will not interfere with phenylalanine products such as BLAST.

Currently, nine amino acid transport systems have been reported to be present at the brain capillary endothelium of the blood-brain barrier, each defined by the common aspects of the amino acids, including the characteristics of the side chains, affinities, and so on. The “L” Transport System, which mediates high affinity, sodium-independent uptake of zwitterionic amino acids—those that carry a total net charge of 0 and are thus electrically neutral, but carry formal charges on different atoms—conveys “large, neutral” side chains across the blood-brain barrier, including L-leucine, L-phenylalanine, L-tryptophan, L-tyrosine, L-isoleucine, L-methionine and L-valine.

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