Biomedical Fast Takes


Galantamine can help you to move to …

The Right Side of the Margin

A new analysis assessed the long-term clinical and economic implications of galantamine in the treatment of mild-to-moderate Alzheimer’s disease (AD) in Germany.1 One of the central ideas of disease prevention and health maintenance is to keep one healthy and alive into the future when greater techniques and therapies are available. In other words, one of the prime goals is to not die on the wrong side of the margin, when living a little longer and crossing to the other side might unveil a life-sustaining discovery.

An economic model to predict the course of AD through changes in cognition, behavioral disturbance, and function over time was developed. The costs and benefits of galantamine versus no-drug treatment and ginkgo biloba were compared. Pooled data from clinical trials, epidemiological and cost data from literature and public data sources were employed.

Galantamine delays average time to severe stage of the disease by 3.57 and 3.36 months, compared to no-drug treatment and ginkgo biloba, respectively. Also, it reduces time spent in an institution by 2.34 and 2.21 months comparitively. Interestingly, the costs were projected to yield net savings of $5,200 per patient versus no-drug and ginkgo biloba treatments. However, these conclusions may be limited by lack of long-term comparative efficacy data, but compared to the considered alternatives, galantamine therapy provides clinical benefits and achieves savings in healthcare costs associated with care for patients with mild-to-moderate AD in Germany. And it might keep you on the right side of the margin.

References

  1. Guo S, Hernandez L, Wasiak R, Gaudig M. Modelling the clinical and economic implications of galantamine in the treatment of mild-to-moderate Alzheimer’s disease in Germany. J Med Econ 2010 Oct 19. [Epub ahead of print]

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