Biomedical Fast Takes

Mastic’s effectiveness is due to its ability to …

Raise Antiinflammatory and Antioxidant Activities

Pistacia lentiscus, the source of the resin mastic gum, has traditionally been used in the treatment of many diseases. In a new study, its resin was investigated for its mineral contents, along with its antiinflammatory and antioxidant activities in rats. Its gallic acid content was determined by HPLC.

Mastic gum produced statistically significant results for the inhibition of edema at all doses when compared to the control groups. A 100% inhibition of inflammation was observed at 800 mg/kg i.p., while the resin exhibited no toxicity at up to 3 g/kg body weights i.p. in mice. Weak nitric oxide scavenging activities were seen, but significant Fe2+ chelating ability were noted. When taken together, these experimental data support the use of mastic resin as an antiinflammatory and antioxidant agent.


  1. Mahmoudi M, Ebrahimzadeh MA, Nabavi SF, Hafezi S, Nabavi SM, Eslami Sh. Antiinflammatory and antioxidant activities of gum mastic. Eur Rev Med Pharmacol Sci 2010 Sep;14(9):765-9.

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