Biomedical Fast Takes


Resveratrol Cranks Up Cognition in Primates

Effects of an 18-month treatment with a moderate, chronic caloric restriction (CR) or an oral supplementation with resveratrol (RSV), a potential CR mimetic, on cognitive and motor performances were studied in non-human primates, grey mouse lemurs (Microcebus murinus).1 In this French study, 33 adult male mouse lemurs were assigned to three different groups: a control group fed ad libitum (fed whenever the lemurs were hungry), a CR group fed 70% of the control caloric intake, and a resveratrol group given a supplement of 200 mg/kg per day ad libitum. Three different cognitive tests, two motor tests, one emotional test and an analysis of cortisol level were performed in each group. Compared to control animals, CR or resveratrol animals did not show any change in motor performances evaluated by rotarod treadmill and jump tests, but an increase in spontaneous locomotor activity was observed in both groups.


Only resveratrol supplementation
increased spatial memory
performances in the
circular platform task.


Working memory was improved by both treatments in the spontaneous alternation task. Despite a trend for CR group, only resveratrol supplementation increased spatial memory performances in the circular platform task. Finally, none of these treatments induced additional stress.


These results suggest that
resveratrol could be a good candidate
to mimic long-term CR effects and
support the growing evidences that
nutritional interventions can have
beneficial effects on brain functions,
even in adults.


This data provides the earliest evidence for a beneficial effect of CR or resveratrol supplementation on specific cognitive functions in a primate. Taken together, these results suggest that resveratrol could be a good candidate to mimic long-term CR effects and support the growing evidences that nutritional interventions can have beneficial effects on brain functions, even in adults.

Reference

  1. Dal-Pan A, Pifferi F, Marchal J, Picq JL, Aujard F; on behalf of RESTRIKAL Consortium. Cognitive performances are selectively enhanced during chronic caloric restriction or resveratrol supplementation in a primate. PLoS One 2011 Jan 31;6(1):e16581.

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