Supplements for Parkinson’s Disease

Q My mother has Parkinson’s and has heard that acetyl L-carnitine can be helpful. Do you have any information about that?

WENDY, North Monmouth, ME

A There is scientific literature supporting the benefit of acetyl L-carnitine (ALC),1 especially when combined with lipoic acid.2 You might also want to investigate curcumin and carnosine;3 CoQ10;4 along with glycerophosphocholine, phosphatidylserine, and omega-3s (especially DHA).5

Also, please research PubMed for further scientific studies at (the U.S. National Library of Medicine website): http://www.ncbi.nlm.nih.gov/pubmed/ and please work with her physician.

References

  1. Sinicropi MS, Leone F, Rovito N, Genchi G. Behavior of acetyl-L-carnitine injections (Nicetile fiale) with different drugs used for combined therapy. Adv Ther 2010 Aug;27(8):547-54.
  2. Zhang H, Jia H, Liu J, Ao N, Yan B, Shen W, Wang X, Li X, Luo C, Liu J Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson’s disease. J Cell Mol Med 2010 Jan;14(1-2):215-25.
  3. Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E. Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochem Res 2008 Dec;33(12):2444-71.
  4. Storch A, Jost WH, Vieregge P, Spiegel J, Greulich W, Durner J, Müller T, Kupsch A, Henningsen H, Oertel WH, Fuchs G, Kuhn W, Niklowitz P, Koch R, Herting B, Reichmann H; German Coenzyme Q(10) Study Group. Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease. Arch Neurol 2007 Jul;64(7):938-44.
  5. Kidd PM. Neurodegeneration from mitochondrial insufficiency: nutrients, stem cells, growth factors, and prospects for brain rebuilding using integrative management. Altern Med Rev 2005 Dec;10(4):268-93.

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