Biomedical Updates


MCT Helps Prevent Fatty Liver

Researchers at Japan’s Kyoto Prefectural University set out to investigate the effects of dietary medium-chain triglycerides (MCT) on liver lipids that accumulation in growing rats with protein malnutrition.1 Rats in the weaning process were either fed a low-protein diet (3%) or control protein diet (20%), in combination with or without MCT.

Rats were fed each experimental diet for 30 days, and four weeks later, the respiratory quotient was higher in the low-protein without MCT diet than in the low-protein plus MCT diet or either of the control protein diets.

Liver triglyceride content increased in the low-protein groups compared with the control-protein groups. However, liver triglyceride content in the low protein plus MCT group was significantly decreased compared to the low-protein without MCT group.

Also, measures of carnitine palmitoyltransferase (CPT) activity were significantly decreased in the livers of the low-protein without MCT group, as compared with corresponding CPT activity of the other groups. The ingestion of a low-protein diet can cause fatty liver in growing rats. Conversely, when rats were fed the low-protein diet plus MCT, liver triglyceride deposition was reduced, and CPT activity was preserved at the levels of rats fed control protein diets. Fatty liver was inhibited.

Reference

  1. Kuwahata M, Kubota H, Amano S, Yokoyama M, Shimamura Y, Ito S, Ogawa A, Kobayashi Y, Miyamoto K, Kido Y. Dietary medium-chain triglycerides attenuate hepatic lipid deposition in growing rats with protein malnutrition. J Nutr Sci Vitaminol (Tokyo). 2011;57(2):13843.

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