Biomedical Updates


Cinnamon Corrects Cognitive Impairment in Alzheimer’s

A growing body of evidence shows that the accumulation of soluble oligomeric assemblies of amyloid-β‚ polypeptide (Aβ) play a key role in the pathology of the disease known as Alzheimer’s (DA). In a new study done at Tel Aviv University in Israel, a specific oligomeric species of Aβ (56 kDa, aka Aβ*56, the name of which is based on the molecular weight of the Aβ structure) was shown to be correlated with impaired cognitive function in DA model mice.1

Several prior reports have documented the inhibition of Aβ plaque formation by compounds from natural sources, but there appears to be a lack of evidence for the ability of common edible elements to modulate Aβ oligomerization. So the researchers set out to identify if cinnamon extract could significantly inhibit the formation of 56 kDa Aβ oligomers and prevents its toxicity on neuronal PC12 cells.

Using a DA-fly model, cinnamon extract rectified their reduced longevity, fully recovered their locomotion defects and totally abolished tetrameric species of Aβ in their brain.

As well, oral administration of cinnamon extract to an aggressive DA-mice model led to marked decrease in 56 kDa Aβ oligomers, to a reduction of plaques, and improvement in cognitive behavior. These results present a novel prophylactic approach for inhibition of toxic oligomeric Aβ species formation in DA through the utilization of a compound that is currently in use in human diet.

Reference

  1. Frydman-Marom A, Levin A, Farfara D, Benromano T, Scherzer-Attali R, Peled S, Vassar R, Segal D, Gazit E, Frenkel D, Ovadia M. Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models. PLoS One 2011 Jan 28;6(1):e16564.

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