Biomedical Updates


Resveratrol Can Help
Prevent Heart Dysfunction

Resveratrol has been found to play a beneficial role in the prevention of diabetes. It also may alleviate some diabetic complications, such as cardiomyopathy. In this light, Turkish researchers investigated the use of resveratrol to treat streptozotocin (STZ)-induced diabetic rats.1 Following induction of chronic diabetes, the rats were divided into two groups, one receiving 10 mg resveratrol/kg of body weight per day* and the other acting as a control group for diabetes. A third group without induced-diabetes was also maintained. The test lasted for four weeks, and at the end of the experiment, the rat’s heart tissues were analyzed with quantitative real-time PCR. The researchers measured cyclooxygenase-1 (COX-1), COX-2, nuclear factor κB (NF-κB), matrix metalloproteinase-9 (MMP-9), and sirtuin 1 (SIRT1) mRNA expression levels.


* This is the equivalent of 138 mg per day for a 187 lb human.


While it was found that there were no significant effects of resveratrol on MMP-9, COX-1, COX-2, or NF-κB mRNA levels among the groups, SIRT1 mRNA levels decreased in the induced-diabetes group compared to the group without diabetes and increased in the induced-diabetes resveratrol group when compared to the induced-diabetes group.

The sirtuin SIRT1 was activated by resveratrol treatment in diabetic heart tissue, and this finding may lead to a new therapeutic approach for diabetic heart tissue complications. Resveratrol use may be able to alleviate heart dysfunction by increasing SIRT1, a protein that in humans is encoded by the Sirt1 gene and which deacetylates proteins that contribute to cellular regulation reaction to stressors. And it may also enhance longevity.

Reference

  1. Yar AS, Menevse S, Alp E. The effects of resveratrol on cyclooxygenase-1 and -2, nuclear factor kappa beta, matrix metalloproteinase-9, and sirtuin 1 mRNA expression in hearts of streptozotocin-induced diabetic rats. Genet Mol Res 2011 Nov 29;10(4):2962-75.

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