Durk Pearson & Sandy Shaw’s®
Life Extension NewsTM
Volume 15 No. 1 • January-February 2012

I consider the foundation of the Constitution as laid on this ground: That “the powers not delegated to the United States by the Constitution, nor prohibited by it to the States, are reserved to the States … or to the people.” [Tenth Amendment.] To take a single step beyond the boundaries thus specially drawn around the powers of Congress, is to take possession of a boundless field of power, no longer susceptible of any definition.

— Thomas Jefferson, Opinion on the Constitutionality of a National Bank, 1791

(D&S Comment: Sadly, many steps have been taken beyond the boundaries “thus specially drawn around the powers of Congress” and we are indeed lost in the boundless field of power by the federal government foreseen by Jefferson. It will be interesting to see whether there is anything whatsoever left of INTRA­state commerce after the Supreme Court rules on whether the Commerce Clause limits federal regulation under Obamacare.)

If you think that science is certain — well that’s just an error on your part.

— Richard Feynman

Standing for office is like a public colonoscopy.

— from Scroogled by Cory Doctorow

Vitamin D3, But Not Other Forms of Vitamin D
Found to Reduce All-Cause Human Mortality

A new review paper1 reports that cholecalciferol (vitamin D3) reduces mortality in adults more than placebo or no treatment but that other forms of vitamin D do not. The other forms that didn’t reduce all-cause mortality included vitamin D2 (ergocalciferol, alfacalcidol, or calcitriol). The meta-analysis reports that vitamin D3 (cholecalciferol) reduced all-cause mortality by 6% (a very impressive reduction!), but not cardiovascular or cancer mortality. (The reason for the finding of reduction in all-cause mortality, but not in cardiovascular (CV) or cancer mortality, which might seem surprising, is that the total number of individuals in the analysis for all-cause mortality were much higher than those for the analysis of CV or cancer; hence, the statistical analysis didn’t have the power to detect a possible effect on the CV or cancer components of the total all-cause mortality.)

The meta-analysis was assembled from reviews of several databases, including MEDLINE, EMBASE, Cochrane Library, and others, to Jan. 2011, plus ongoing trial databases and reference lists to find randomized controlled trials where human subjects were taking supplemental vitamin D or no intervention in adults =18 years of age who were healthy or had stable disease (not including secondary-induced osteoporosis or cancer or women who were pregnant or lactating) or vitamin D deficiency. That included 50 trials of 94,148 subjects with mean age 74 years and of which 79% were women.

The commentary2 on the review concluded that “... the results of the meta-analysis by Bjelakovic and colleagues should encourage providers to consider cholecalciferol (vitamin D3) as their preferred choice for vitamin D supplementation.”


  1. Bjelakovic et al. Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev 2011;(7):CD007470
  2. Murff. Commentary” (same page of same issue of journal given in reference #1 above)

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