GalantaMind Plus—Better with Memory Upgrade

Q I have been taking 4 capsules of GalantaMind Plus daily for quite a few years, and I love it. What would I take to get the added benefit of choline alphoscerate, which Life Enhancement recently wrote about as an effective choline donor and acetylcholine precursor?

LEANNE, Sherman Oaks, CA

A We also wrote that choline dihydrogen citrate is the way to go, because it is also a very effective choline donor, and much less expensive than choline alphoscerate. Increasing the choline in your diet—along with vitamin B5 (pantothenate), which helps convert the choline to acetylcholine—could be very useful. How much you need depends on your age.

In an interesting article that appeared in JAMA called “Decreased Brain Choline Uptake in Older Adults,”1 it was found that as you get older, the ability of choline to cross the blood-brain barrier into your brain drops dramatically. At the age of 65, or thereabouts, you may have only about 30% of your young-adult capability for transporting choline across the blood-brain barrier. This can be a real problem.

When The Institute of Medicine decided that choline is an essential nutrient for humans a few years ago, they recommended a dose of 550 mg/day for men and 425 mg/day for women, noting that most American diets don’t provide even that much. Considering that the ability of choline to get into your brain drops by about 70%, beware! Your brain is going to be extremely choline-deficient by age 65 unless you’re taking a much larger choline supplement.

As part of Durk Pearson & Sandy Shaw’s brain-maintenance formulation, they provide 2 to 3 grams of choline per day in the form of a tasty drink mix, Memory Upgrade. Even with a 70% reduction in the transport of choline into your brain, this will still give you choline levels that are higher than you would have had as a healthy young adult. They want to make sure that your brain isn’t starved for choline, because there’s a very serious consequence. If you don’t make enough acetylcholine, neurons die off when they are cannibalized for the choline contained in their membranes. Don’t let this happen to you.


  1. Cohen BM, Renshaw PF, Stoll AL, Wurtman RJ, Yurgelun-Todd D, Babb SM. Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study. JAMA 1995 Sep 20;274(11):902-7.

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