Durk Pearson & Sandy Shaw’s®
Life Extension NewsTM
Volume 15 No. 3 • June/July 2012

Two Strains of Lactobacillus, Lactic Acid Bacteria,
Identified As Inhibitors of Helicobacter pylori Infection

In another recent paper1 researchers have identified two strains of Lactobacillus, L. gasseri Chen and L. plantarum as having significant anti-Helicobacter pylori activity. Helicobacter pylori is a bacteria that resides in the gastro­intestinal tract of more than half of the world’s human population1 and that can cause serious disease (chronic gastritis, peptic ulcer, or gastric cancer) but only does so in a fraction of those infected with it.

Helicobacter pylori was tested for its ability to adhere to human gastric epithelial cells (SGC7901 cells) in the presence of the two lactobacilli. After two hours of incubation in cell-free supernatants from the lactobacilli, the activity of an enzyme (urease) released by H. pylori adhering to the SGC7901 cells was reduced from 100% to approximately 50%.

The authors point out that these Lactobacilli can be used as probiotics to manufacture dairy products that could reduce the risk of H. pylori-induced disease. What these scientists may not realize, however, is that the FDA would deem a health claim of disease risk reduction to make a food such as yogurt (or other dairy product) containing the Lactobacilli into a drug. It could be marketed without the claim, of course, but that would make it much more difficult to sell.


  1. Chen et al. Antagonistic activities of Lactobacilli against Helicobacter pylori growth and infection in human gastric epithelial cells. J Food Sci 71(1):M9-M14 (2012).

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