Durk Pearson & Sandy Shaw’s®
Life Extension NewsTM
Volume 15 No. 4 • August 2012


APPETIZERS

Though many have tried, no one has ever yet explained away the decisive fact that science, which can do so much, cannot decide what it ought to do.

— Joseph Wood Krutch, “The Loss of Confidence” in The Measure Of Man (1954)

(D&S: It may have something to do with the undeniable fact that “science” makes no decisions at all and that scientists as a whole are unlikely to agree on anything involving subjective values.)

As Charles Darwin once said, “Mathematics seems to endow one with something like a new sense.”

Darwin would have been amazed at the incredible increase in the rates of computational power since his time. “In our recent past, it took 30 years to determine the complete DNA sequence of a cold virus genome. Today a virus of the same size can be sequenced in minutes. We can now read more than 500 billion bases in a week, compared to 25,000 in 1990 and 5 million in 2000.”

— quotes from Perdue, “Mathematics Transforming Bioresearch,” Genetic Engineering & Biotechnology News May 1, 2012 genengnews.com

Being able to redesign systems whether it’s with genetics or whether it’s with drugs is going to be at the heart of the new kind of medicine that will emerge from systems biology—P4 Medicine —that is, predictive, personalized, preventive, and participatory medicine.

Dr. Hood gives an example of how personalized medicine can work. “A friend of mine at Microsoft had a defect in vitamin D transporters and was suffering from osteoporosis. To reverse his osteoporosis, all he had to do was take 20 times the normal amount of vitamin D.”

— LeRoy Hood, quoted in above article

(D&S: Fortunately for Dr. Hood’s friend, he didn’t have to wait for umpteen years for FDA approval for the vitamin D remedy because of vitamin D availability as a dietary supplement. A lot of others are not so lucky.)

The great book of nature can be read only by those who know the language in which it was written. And this language is mathematics.

— Galileo

“52% Say States Should Be Allowed to Overrule Feds on Drug Approval”

In a telephone survey of 1,000 likely U.S. voters conducted on May 12, 2012, Rasmussen Reports found that 52% “believe that if a state government feels a drug has benefits in some circumstances, it should be able to approve sale of that drug within its borders” even when the FDA has already denied approval. 32% disagreed, while 16% were not sure.

(D&S: The Tenth Amendment to the U.S. Constitution provides that: “The powers not delegated to the United States by the Constitution, nor prohibited by it to the States, are reserved to the States respectively, or to the people.” There is NO power delegated to the United States to regulate the practice of medicine just as there is NO power delegated to the U.S. to determine what you can or cannot eat. Nobody is likely to imagine that there could not be costly errors made in a system free of FDA drug approval, but the costs of these errors have to be compared not to perfect decision-making but to the existing flawed and very expensive system of FDA drug approval.

Does the Tenth Amendment have any effect on federal government action today? Surprisingly, it does. See the special article at the end of this issue on a 2011 U.S. Supreme Court decision where the Court unanimously upheld the right of a woman to challenge her criminal conviction under a federal statute on the basis of the Tenth Amendment!)

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