Hydrogen dose calculations

Q How is the amount of the long-chain fructooligosaccharides prebiotic in Hydrogen Power calculated, the amount necessary to produce significant hydrogen release?

CHARLES, London, UK

A In many of the studies to date, hydrogen water and hydrogen saline are used. One reason for the use of these carriers is that it is possible to reliably control the dose administered to experimental animals, which is important in determining results such as dose-response relationships. However, with gut bacteria-provided hydrogen, it is not as easy to determine the hydrogen “dose,” although one way to partially overcome this problem is to measure the hydrogen gas excreted by the lungs.

According to Durk Pearson & Sandy Shaw, “As noted in the paper[1] ‘[i]ngestion of fructans is limited by various abdominal symptoms such as osmotic diarrhea, pain, bloating, and flatulence due to colonic fermentation and production of bacterial end-products,’ including hydrogen gas. These side effects occur more frequently with the shorter-chain inulin fructans and with higher doses.[1] ‘A dose of 5 g/d seems to be well tolerated,”[1] whereas higher amounts may induce one or more of the aforementioned annoying side effects, primarily flatulence. A further way to limit the likelihood of having uncomfortable bloating from gas is to take a small quantity of simethicone to break up gas bubbles.” [See “Hydrogen Therapy” in the June 2012 issue of Life Enhancement.]

Reference

  1. Rumessen and Gudmand-Hoyer. Fructans of chicory: intestinal transport and fermentation of different chain lengths and relation to fructose and sorbitol malabsorption. Am J Clin Nutr 1998;68:357-64.

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