The French Paradox explodes under a new wave of scientific scrutiny ...

Resveratrol Research Soars
by Dr. Joyce Block
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ACROSS

3. Researchers started to ask what in red wine could be the cause of the benefit. Their answer was ___. Clue: From the dried root of white hellebore as well as other plants

6. Known as Huzhang, Japanese Knotweed has long been used to maintain proper blood ___ and to control inflammatory processes. Clue: The biological organ system whose primary function is to move substances to and from cells

9. In the 1997 study, the antiinflammatory activity of resveratrol could be shown in vivo at a dose of 8 mg/kg body weight/day corresponding to a human equivalent dose of about 90 mg/day for a 154 lb human. Clue: The quantity of a substance

10. In 1997, researchers suggested that the effect of resveratrol on cellular events associated with carcinogenesis, including tumor initiation, promotion, and progression is attributable, in part, to its antiinflammatory properties. Clue: Disorder of structure or function in a human, animal, or plant

11. Altogether, studies to date ____ indicate that resveratrol has beneficial effects on human circulatory function. Clue: Convincingly; makes you realize that you can be intellectually confident

12. The explanation of why high consumption of saturated fat by the French did not result in high levels of cardiovascular disease is called the French ___. Clue: Contradiction

14. A great many biological benefits have been attributed to ___, including antioxidant, anti-inflammatory, anticarcinogenic, antiaging, and cardiovascular protective properties. Clue: The subject of this article which appears twice as an answer

15. In a study reported in Cell Metab., 2011, resveratrol significantly reduced ___ blood pressure and improved blood glucose levels as well as insulin sensitivity in human obese men receiving 150 mg/day of resveratrol for 30 days. Clue: The top number in your blood pressure reading

DOWN

1. A rapid acceleration in knowledge and MEDLINE publications about resveratrol has occurred since 2010. Life Enhancement’s first article on resveratrol was published in July of 2000 about the prospects of the research. Clue: Predictions (i.e., a reason you should stick with us)

2. Interest in resveratrol continues to grow and produce significant conclusions, especially regarding its beneficial effects on aging, along with positive effects for metabolic and cardiovascular ____. The personal issue that is central to the fact that you are reading this article: rhymes with wealth

4. Nitric oxide (NO) is a potent ___ involved in the regulation of vascular homeostasis and is produced by endothelial nitric oxide synthase (eNOS). Clue: The widening of blood vessels; a good thing when you want to decrease your blood pressure

5. In vitro assays showed that resveratrol might well be able to protect the cardiovascular system by inhibiting platelet aggregation and LDL ___. Clue: The chemical combination of a substance with oxygen, like rust.

7. In a human study, resveratrol acutely enhanced the release of ____ from endothelial cells, with one paper showing that at very low doses, resveratrol increased functional eNOS protein and NO production. Clue: a potent vasodilator; opposite of YES

8. Much of the outline and details of the lead article in this issue are derived from an Annals of The New York Academy of Sciences report. Clue: Fine points; the truth of something is found in the ______

13. While resveratrol is found notably in ____ and in a variety of medicinal plants, the principle source of commercial use is from the Japanese Knotweed. Clue: Berries that lives on vines

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