The Durk Pearson & Sandy Shaw®
Life Extension NewsTM
Volume 16 No. 8 • September 2013


Hydrogen Treatment Prevents Lipid Deposition in Descending Aorta in Rat Model of Periodontitis

As we have mentioned in this newsletter before (in the context of bacteria found in tooth decay being involved in the development of atherosclerotic plaques), the connection between periodontitis and atherosclerosis is becoming supported by more data (hypothesis under development). In this very interesting paper,1 scientists have shown in a study of rats with induced periodontitis that lipid deposition occurred in the descending aorta, but when a similar group of rats with induced periodontitis was treated with hydrogen (as hydrogen-rich water), those rats had a significantly lower level of lipid deposition in their descending aortas. Hence, the results of this study if verified in people could be of major importance to a great many people with periodontitis, who may be unknowingly vulnerable to a silent source of atherosclerosis.

The researchers propose that the reduced lipid deposition was a result of decreased serum oxidized LDL and decreased aortic oxidative stress. The periodontal tissue examined showed infiltration by inflammatory cells, which was reduced in the group receiving hydrogen water therapy. Importantly, results showed that “[l]ipid deposition in the descending aorta was observed in all rats in the periodontitis group and in none of the rats in the control or periodontitis + HW [hydrogen water] groups.”1


  1. Ekuni et al. Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model. Arch Oral Biol. 57:1615-22 (2012).

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