Biomedical Updates


Omega-3 Fish Oil Lowers Inflammation Markers

E arlier studies have not drawn a consistent conclusion about the effects of Omega-3 Fish Oil on fasting blood level of C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α).

However, a new meta-analysis based on a comprehensive search of Web of Science, PubMed, Embase and Medline (from 1950 to 2013) and bibliographies of relevant articles was conducted.1 Sixty-eight randomized control trials with a total of 4,601 subjects were included in the study. Omega-3 supplementation had a significant lowering effect on TNF-α, IL-6 and CRP in three groups of subjects (subjects with chronic non-autoimmune disease, subjects with chronic autoimmune disease and healthy subjects).

Also, there was a significant negative linear relationship between duration and effect size of marine-derived n-3 PUFAs supplementation on fasting blood levels of TNF-α and IL-6 in those with chronic non-autoimmune disease. This indicated that longer duration of supplementation could lead to a greater lowering effect. A similar linear relationship was also observed for IL-6 levels in healthy subjects.

Noteworthy, analysis showed that the lowering effect of Omega-3’s on CRP, IL-6 and TNF-α in subjects with chronic non-autoimmune disease became weakened when body mass index was greater than 30 kg/m2.

Marine-derived Omega-3 supplementation had a significant lowering effect on the inflammatory markers CRP, IL-6 and TNF-α level. The lowering effect was most effective in non-obese subjects and consecutive long-term supplementation was recommended.

Reference

  1. Li K, Huang T, Zheng J, Wu K, Li D. Effect of Marine-Derived n-3 Polyunsaturated Fatty Acids on C-Reactive Protein, Interleukin 6 and Tumor Necrosis Factor α: A Meta-Analysis. PLoS One. 2014 Feb 5;9(2):e88103. doi: 10.1371/journal.pone.0088103.

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