The Durk Pearson & Sandy Shaw®
Life Extension NewsTM
Volume 17 No. 4 • May 2014

Aspirin-induced Gastric Damage Inhibited by Hydrogen Administered in Drinking Water to Rats

Gastric mucosal damage induced by aspirin or other NSAIDS (non-steroidal antiinflammatory drugs such as ibuprofen) is a frequent side effect of these pain killers. Using the aspirin gastric mucosal injury as a model in rats of these effects in humans to study how hydrogen is able to provide protection was reported in a new study.1 At the same time, the researchers investigated whether there is a dose-response relationship for hydrogen in its protective effects against gastric mucosal injury and why a dose-response relationship has not been observed in other studies of hydrogen’s protective effects, as seen in cerebral infarction (stroke), ischemia/reperfusion, metabolic syndrome, Parkinson’s disease, and other human diseases and disease models.1

With respect to the dose-response relationship, the scientists observed such a relationship in the stomach, but not in the serum which suggests, they believe, that “a dose response effect exists when hydrogen interacts directly with the tissue, but a high dose of hydrogen may not increase the beneficial effects in target organs via blood transportation.” Apparently, the hydrogen reaches the stomach at a certain concentration but that after leaving the stomach, it is diffused through the body’s tissues and also excreted rapidly, thus the concentration available to other tissues is much lower than in the stomach. The amount of hydrogen was adequate, however, to alkalize the water which inhibited increased urinary excretion of minerals such as calcium and magnesium.

The scientists observed that hydrogen protected against aspirin-induced gastric mucosal injury in a dose-dependent manner.


  1. Xue et al. Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water. BMC Complement Altern Med. 14:81 (2014).

FREE Subscription

  • You're just getting started! We have published thousands of scientific health articles. Stay updated and maintain your health.

    It's free to your e-mail inbox and you can unsubscribe at any time.
    Loading Indicator