The Durk Pearson & Sandy Shaw®
Life Extension NewsTM
Volume 17 No. 7 • August 2014


Selenium, Magnesium, and Zinc Appear to Be
Important Determinants of IGF-1 Bioactivity

A point where several elements involved in human aging seem to come together is the IGF-1 (insulin-like growth factor-1) pathway, where its decline is associated with frailty.1 A very recent review paper explored this subject, noting that the minerals selenium, magnesium, and zinc appear to be important determinants of IGF-1 bioactivity. In the papers we discussed in an earlier newsletter on senescence, deficiencies of selenium and magnesium are shown to be important in the senescence of cells in age-associated sarcopenia (loss of muscle mass). The authors of the paper describe frailty as the result of an interplay of multiple factors including hormones, pro-inflammatory status, oxidative stress, and nutrition and explain that “frailty is a geriatric syndrome occurring in the early stages of mobility impairment and is not a synonymous or consequence of co-morbidity or disability.”


  1. Maggio et al. IGF-1, the crossroad of the nutritional, inflammatory, and hormonal pathways to frailty. Nutrients. 5:4184-205 (2013).

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