Get out your eraser …
Galantamine Reduces Brain Shrinkage
by Dr. Joyce Block


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ACROSS

3. ApoE is a class of apolipoproteins found in the chylomicron and intermediate-density lipoprotein (IDLs)—two of the five major groups of lipoproteins, together with VLDL, LDL, ______. Clue: The good cholesterol whose number you want to be high (acronym).

6. If anyone in your family has had either memory problems or been diagnosed with AD, ______ have an increased risk of possessing the dreaded ε4 variant of ApoE. Clue: The person you see when you look in the mirror.

9. The bottom line regarding the much sought after ApoE test is that you can’t ban information. Quoting Ms. Wojcicki, the CEO of 23andMe, (and echoing Victor Hugo’s famous quote), “So how do you ______ information? Clue: Control.

10. AD brain imaging studies demonstrate progressive reduction in whole brain volumes and volumes of the ______, hippocampus, and parahippocampal gyrus. Clue: Part of the brain that has a primary role in the processing of memory, decisionmaking, and emotional reactions. Also, part of brain that “appears” to play a role in binge drinking, and damage through repeated episodes of intoxication and withdrawal. Fascinating stuff!

11. The ______ effect of galantamine on whole brain atrophy rate in MCI was only present in apolipoprotein E (ApoE) ε4 carriers. Individuals with APOE ε4 carriers are significantly more susceptible to Alzheimer’s disease. Clue: How effective parents act with very young children.

12. Forbes magazine interviewed the company 23andMe’s CEO Anne Wojcicki, the provider of an ApoE test for $99. The test was declared a new medical device and was ______ in November of 2013. Clue: Prohibited.

15. Arthur Conan Doyle speaks of being on the edge of an abyss, which is the metaphor Will Block uses in describing mild cognitive ______. Clue-a damaged or weakened state

16. Testing for ApoE is possible but the ______ has a ban on it currently. Clue: Federal agency responsible for advancing the public health by helping to speed innovations that make medicines more effective, safer, and more affordable … (from fda.gov)

DOWN

1. Dementia ia a disease in which cell damage leads to tissue ______ and reduced function in the brain’s frontal and temporal lobes. Clue: Reduction in volume.

2. Our brains’ frontal and temporal lobes control planning and judgment functions, emotions, speaking and understanding speech, and certain types of ______. Clue: Motion.

4. The sad news is that mild cognitive impairment (MCI) is projected to approach ⅓ or more of the > 65 ______ the future. Clue: Peeps (slang).

5. As readers of this publication know very well, acetylcholinesterase inhibitors (AChE inhibitors) such as ______ have previously been shown to exhibit a neuroprotective effect via the nicotinic acetylcholine receptor-mediated cascade.

7. ApoE ε4 allele positive patients suffer ______ disordered breathing and poorer performance on cognitive tests. Clue: As Shakespeare wrote, “To ______ perchance to dream.”

8. Galantamine demonstrated, in a new study, a lower rate of whole brain atrophy (degeneration) than those receiving a ______. Clue: A substance with no therapeutic effects.

13. It has also has been reported that AChE inhibitors hinder the progress of brain atrophy in AD, indicating the lessening of neuronal ______ in the brains of the patients. Clue: AKA The Grim Reaper.

14. Defects in the ApoE ε4 allele result in impaired clearance of chylomicron, VLDL and LDL (the ______ cholesterol) remnants. Clue: What Michael Jackson told us about himself in a song, “I’m … .”

Crossword Contest
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Submitting a correctly answered puzzle each
month by the 15th of the next month.

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Attn: Dr. Joyce Block
Life Enhancement Contest
2555 Business Parkway
Minden, Nevada 89423

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