Resveratrol through time …
Protecting the Threads of Memory
by Dr. Joyce Block


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ACROSS

1. The French ______, a question raised at the end of the 20th century, asked why the high-fat diet of the French did not cause more heart disease. Clue: contradiction

3. In a neuroprotective study, findings offer the basis for the increased use of resveratrol to ______ brain health during aging. Clue: retain

4. Since inflammation plays a major role in the pathogenesis of disease, agents that suppress inflammation have a potential in moderating the symptoms. ______ is one of these! Clue: a phenolic compound, a stillbene, found in red wine

7. Data collected as far back as 1997 indicates that phenolic compounds found in red wine exhibit properties that may account for the fact that long term moderate drinking of red wine can protect against coronary heart ______ . Clue: lack of ease; a word describing what you are trying to prevent by taking supplements and becoming health smart

8. In conclusion, the researchers found that resveratrol could prevent cognitive deficits as well as the oxidative stress caused by streptozotocin, a brain ______ substance, in rats noting its potential in the treatment of neurodegenerative diseases such as AD. Clue: poisonous

9. Another memory-enhancing paper shows that resveratrol improves ______ and reduces oxidative stress in rats with vascular dementia. Clue: reasoning, an increasingly rare perceptual method of acquiring knowledge (author’s observation)

11. The history of resveratrol—found as an active ingredient in red grapes, peanuts, berries, and several other food plants — meanders back to the Ayurveda, the ancient Indian treatise on the “science” of ______ . Clue: long life

12. There are lots of reasons to take resveratrol, along with the ______ quercetin that is also found in red wine as a co-compound polyphenol. Clue: plant pigments

13. When thinking about the issues and problems of aging, we should point our nutritional fortifications and ______ in order to reap more memory benefits. Clue: tools for gaining an advantage, like acquiring knowledge by reading these and other articles

14. Treatment with resveratrol decreased ______ and increased cortex/hippocampus-dependent memory of animals subjected to blunt head trauma. Clue: what most humans experience when they face an uncertain future


DOWN

1. In a new paper, researchers tested whether resveratrol would enhance memory performance in older adults. Altogether, this study provides initial but ______ evidence that supplementary resveratrol improves memory performance. Clue: evidence with a “pow”

2. A memory-enhancing paper shows that reservatrol protects mice against spatial learning loss from ______ consumption. Clue: alcohol (Maybe you should have known this before your last party!)

4. Resveratrol was first identified by a Japanese researcher in 1940 as a constituent of the roots of white hellebore and later in the dried ______ of Polygonum cuspidatum, called Ko-jo-kon in Japanese, or knotwood, today. Clue: botannical beginnings

5. The leap in resveratrol research was propelled by two groundbreaking studies published in 2003 and 2006. The senior author was David Sinclair of Harvard University’s Paul Glenn’s ______ of Mechanisms of Aging. Clue: scientific research facility

6. Throughout our magazines, a coyote appears to instruct us, to show us things metaphorically in amusing scenarios. His persona is taken from Albert ______ . Clue: a really really smart guy

10. Resveratrol has been shown to increase memory performance in primates; however, interventional studies in older humans are lacking. UNTIL ______ . Clue: Currently (How exciting is this!)

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