The most newsworthy ingredients of 2014

Nutrients of the Year
An expanded universe of health coverage

By Will Block


A protected stomach protects the brain.
A t Life Enhancement, choosing what to write about significantly reflects what we believe to be most valuable nutrients you can take. Realizing that you can’t take them all, each month we do our best to introduce new nutrients (e.g., potassium bromide) or report new information on formerly studied and recommended nutrients.

Without further ado, here are the most written about nutrients in 2014.

The #1 nutrient is GALANTAMINE

… and that’s not surprising given the rave reviews:

From EMILY Cheyenne, WY—I am one of those vitamin-junkies. I take a LOT of vitamins. I have been using your top-end galantamine formulation for the last few years, and I’m still here! I find that it seems to work great. I started out slow on it, and it seemed to be working well, so I keep on taking it!

From ROY Portland, OR—I really think that your top-end galantamine formulation is a fantastic product. I honestly don’t know any other 90 year olds who have the same cognitive power that my wife and I have. I really don’t, and I don’t want to lose that. It’s expensive but it’s so much better than a lot of the other stuff out there!

From Cecil Rising Sun, MD—I’ve noticed quite an improvement using galantamine. It really works – so much so that I keep ordering it. The only downside is the premium cost. But if you want to dance you have to pay the piper!

From JOEL San Diego, CA—We had read some articles on galantamine and decided to purchase some for our sister-in-law to see if it would help hers. This is an incredible product, and we noticed huge improvement within a couple of months. At one point the family took her off of it, and she regressed in about 3 weeks. We now have her back using it and not only is she good as new, she’s even better!

From RACHMAEL San Francisco, CA—I’ve been taking galantamine for years. It’s easy to take and swallow. Questions and events and people from the past seem clear. Just the other day I received a call from a person I haven’t heard from in 40 years and I remembered his first and last name! Whatever galantamine is doing for my mind is wonderful.

From DANIEL MO—I started taking galantamine about 7 months ago, which was recommended as a supplement by my physician. I’m a musician, and I noticed I was forgetting certain music chords that I had known by heart for years. Since taking this product I have had great success—better than I had even been in the past. If a miss a few days of taking this supplement, I notice I’m not as sharp. I need my galantamine to stay sharp.

From TERESA WA—I have had a great memory, but I was starting to lose it and get a bit funny. I actually got lost driving once before I started taking the galantamine. My husband even bought me a GPS! And now—I cannot believe how much better I am. I play all sorts of games and everything I do now is really excellent—it really works I tell you! When I bought my other supplements from my local store, I told the manager that he does not have any products like galantamine and he said that he would investigate it! I don’t know how to express how wonderful this product is.

From ALEX Bevan Australia—I am very happy with galantamine. It has helped my wife a great deal. She has come back to me; not a 100%, but I have my girl 90% back with me. My family is amazed with the difference in her whole attitude, and I hope it continues.

From HENRY Wichita, KS—I just read your article “Improve Episodic Memory” in the July issue and here’s my story. Over the years I’ve always enjoyed reading to my kids when they were growing up. Also, I would tell them stories derived from my life experience, a habit and a delight that I had continued with my grandchildren. However, a few years ago, both reading to the grandkids and telling my stories became a chore, and to my chagrin and anguish, I backed off. Then I started taking your top galantamine formulation, and after about a year, although my grandchildren are now older, I’ve resumed again. Once more, the images are alive. What a pleasure!

I saw a movie called Inkheart a few months ago about a father who has the ability to bring the characters of the books that he reads to life and into the real world. His 13-year old daughter develops the same faculty in the dénouement of the film. While it’s just a fantasy, I was deeply touched, and gratified that, in a way, I too had the ability to enchant my own grandchildren once again. Thank you.

This past year, we have reported that:

  • Galantamine is further enabled as a memory enhancer even more when the ulcer-causing bug H. pylori is eradicated (as mastic can help to do) (See the March 2014 issue, “Ulcer Bug Eradication Empowers Galantamine”)

  • Galantamine is further enhanced with hesperidin, which can help protect your brain from the ravages of aging and, based on newer discoveries about it, may help reduce the risk of Alzheimer’s disease. (See the April 2014 issue, “Improved Galantamine Formulation at No Extra Cost”)

  • Galantamine battles Alzheimer’s disease, which is all the more important because a new analysis shows it to be the third leading cause of death in the US, rivaling heart disease and cancer, with over 504,000 deaths attributed to it in 2010. (See the May 2014 issue, “Alzheimer’s Deaths Rival Cancer’s”)

  • Galantamine targets vasculature and also skeletal satellite cells, helping to accelerate muscle growth. (See the July 2014 issue, “Galantamine Preserves Muscles”)

  • Galantamine promotes hippocampal neurogenesis—i.e., the creation of new neurons! (See the July 2014 issue, “Galantamine Births Neurons”)

  • Galantamine lowers the rate of brain degeneration in those with mild cognitive impairment. (See the October 2014 issue, “Galantamine Reduces Brain Shrinkage”)

  • Galantamine mediates the inflammatory effects of proinflammatory cytokines, and may be an important weapon to fight the cytokine storms that characterize lethal viruses that may cause death. (See the December 2014 issue, “Foiling Cytokine Storms with Cholinergics”)

The #2 nutrient of the year is TURMERIC

This ancient herb (and food) contains the curcuminoids, which are heavily touted by researchers. However, the curcuminoids are not the only active compounds found in turmeric, some of which are just as important as the curcuminoids, and which enable greater bioavailability, a problem with curcuminoids.

This past year, Life Enhancement reported that:

  • Turmeric inhibits chronic inflammation induced by exposure to lipopolysaccharide and interferon-gamma-induced nitrite production in mouse peritoneal cells by more than 50% with no evidence of general cellular toxicity. (See the February 2014 issue, “Some Supplements Can Reduce Chronic Overexpression of Innate Immune System—a Few Examples” in the February issue of Life Extension News)

  • Turmeric reduces plasma fibrinogen, high levels of which have been clearly implicated in aging and numerous age-related diseases. (See the March 2014 issue, “Drugs, Supplements, and Test Results” in Ask Dr. Dean)

  • Turmeric relieves depression associated with higher levels of pro-inflammatory cytokines and pain by increasing serotonin levels. (See the May 2014 issue, “Announcing Durk & Sandy’s … New Lithium Formulation”)

  • Turmeric helps reduce mild stress-induced depressive-like behavior, reverse impaired hippocampal neurogenesis, and increase brain-derived neurotrophic factor in chronically stressed rats. (See the May 2014 issue, “Announcing Durk & Sandy’s … New Lithium Formulation”)

  • Turmeric shows antidepressant-like activity in chronically mildly stressed rats (partially due to curcumin’s anti-inflammatory effects), and demonstrates effective treatment of depressive-like behavior in mice. (See the May 2014 issue, “Announcing Durk & Sandy’s … New Lithium Formulation”)

  • Reported (as curcumin) to be safe and effective in major depressive disorder in a human randomized controlled trial. (See the May 2014 issue, “Announcing Durk & Sandy’s … New Lithium Formulation”)

  • Turmeric may increase expression of the thermogenesis gene Ucp1 (uncoupling protein 1) that increases energy expenditure in brown fat, lending support for the use of curcumin (found in turmeric root) in weight control regimens. (See the June 2014 issue, “Increasing Thermogenesis of Brown Fat With A Supplement” in the June issue of Life Extension News)

The #3 nutrient of the year is EGCG

In epidemiological studies, tea (and especially green tea) has been shown to provide major health benefits. But now with an increasing number of scientific studies about its catechins (and especially EGCG (epigallocatechin gallate), the benefits keep rising, the applications keep increasing, and at levels that often exceed what one could reasonably drink over the course of a day.

This past year, Life Enhancement reported that:

  • EGCG inhibits chronic inflammation induced by exposure to lipopolysaccharide and interferon-gamma-induced nitrite production in mouse peritoneal cells by more than 50% with no evidence of general cellular toxicity. (See the February 2014 issue, “Some Supplements Can Reduce Chronic Overexpression of Innate Immune System—a Few Examples” in the February issue of Life Extension News)

  • EGCG promotes the Dopaminergic Reward System by inhibiting COMT (catechol-O-methyltransferase), an enzyme that metabolizes catecholamines (degrading dopamine and adrenaline/noradrenaline) and can be a powerful element of human behavior and, indeed, of the pursuit of happiness. (See the March 2014 issue, “Would You Like To Enjoy Life More?”)

  • EGCG has its bioavailability increased by Vitamin C which has been found to help maintain catechin (EGCG is a catechin) content in ready-to-drink tea beverages. (See the March 2014 issue, “Would You Like To Enjoy Life More?”)

  • EGCG has its intracellular concentration increased by quercetin. (See the March 2014 issue, “Would You Like To Enjoy Life More?”)

  • EGCG inhibits psychostimulants-induced hyperactivity in part by modulating dopaminergic transmission (See the May 2014 issue, “Rewards Trigger Bigger Learning Response with Green Tea” in the May issue of Life Extension News)

  • EGCG has been shown to reduce hypothalamic-pituitary-adrenal axis hyperactivity in response to stress in mice. (See the May 2014 issue, “Rewards Trigger Bigger Learning Response with Green Tea” in the May issue of Life Extension News)

  • EGCG has been reported to significantly increase calmness and reduce stress. (See the May 2014 issue, “Rewards Trigger Bigger Learning Response with Green Tea” in the May issue of Life Extension News)

  • EGCG may be a beneficial agent in the prevention of development or progression of Alzheimer’s disease. (See the May 2014 issue, “Rewards Trigger Bigger Learning Response with Green Tea” in the May issue of Life Extension News)

  • EGCG suppresses gluconeogenesis in liver cells, protecting against major pathway leading to excess blood sugar in type 2 diabetes thus pointing to a new therapeutic approach for the management of diabetes. (See the May 2014 issue, “Rewards Trigger Bigger Learning Response with Green Tea” in the May issue of Life Extension News)

  • EGCG may increase expression of the thermogenesis gene Ucp1 (uncoupling protein 1) that increases energy expenditure in brown fat, lending support for the use of EGCG in weight control regimens. (See the June 2014 issue, “Increasing Thermogenesis of Brown Fat With A Supplement” in the June issue of Life Extension News)

  • EGCG is essential for Ebola virus infection protection because it inhibits the chaperone HspA5. These findings demonstrate that HspA5 is vital for Ebola replication—but when blocked, the growth of the virus is halted under laboratory conditions. (See the November 2014 issue, “EGCG Inhibits Ebola Replication”)

  • EGCG is a naturally occurring demethylating agent. (See the November 2014 issue, “Important New Discovery! New Way To Prevent Atherosclerosis”Life Extension News)

  • EGCG is natural fatty acid synthase inhibitor, which may be potentially protective against infectious disease on the interpretation of in vitro, animal, and human studies. Also EGCG has been shown to inhibit a molecule that may be essential for Ebola viral infection. A 2014 paper reports that in vitro EGCG bound to a site on the molecule preventing it from promoting viral cellular entry. (See the December 2014 issue, “Surviving Deadly Viral Epidemics”)

The #4 nutrient of the year is DHEA

After all these years, DHEA (dehydroepiandrosterone) is still garnering applause for its importance to good health.

This past year, Life Enhancement reported that:

  • DHEA was offered FIRST by Life Enhancement as an over-the-counter supplement. (See the January 2014 issue, “Low Durability of DHEA?” Ask Dr. Dean”)

  • “DHEA levels are highest in the morning, and decline progressively throughout the day. Therefore, I recommend taking your DHEA first thing in the morning.” (See the February 2014 issue, “DHEA Diurnal Rhythms?” Ask Dr. Dean”)

  • DHEA supplementation has been reported in a number of studies to have positive effects on bone density and reversal of osteoporosis. (See the November 2014 issue, “Oral Chelation Or IV Chelation To Improve Bone Density?” Ask Dr. Dean”)

  • High DHEA Levels decrease heart disease and may increase survival and thus prolong life. (See the December 2014 issue, “High DHEA Levels Decrease Heart Disease”)

  • DHEA levels associated with survival. (See same reference as above for this and everything else that follows)

  • DHEA helps tumor prevention

  • DHEA helps lower cholesterol

  • DHEA associated with a healthier heart

  • Low DHEA levels may increase mortality

  • DHEA may normalize some effects of aging

  • DHEA at 25 – 50 mf/day safe in the elderly

  • DHEA may reduce cognitive deficits

  • DHEA supports the creation of new neurons

  • DHEA helps Parkinsonian disease and schizophrenia

  • Low DHEA-S associated with increased pain and distress

  • DHEA decreases cholesterol, insulin, and glucose

  • DHEA enhances muscle mass in the elderly

  • DHEA restores sex hormones of elders to younger subjects

  • Low DHEA associated with gait and memory

  • Lower DHEA-S associated with higher CVD mortality and all-cause mortality

  • DHEA improves fertility and increases live births

  • Inhaled DHEAs improved asthma

  • DHEA lowers inflammatory cytokines in aging humans

  • DHEA improves cognition in older women

  • DHEA improves pulmonary hypertension

  • DHEA reverses arterial aging and reduces CVD risk

The #5 nutrient of the year is Vitamin D

Vitamin D had a long history before Adolf Windaus appeared on the scene and received a Nobel Prize for his work in 1928. Rickets, the bone disease caused by vitamin D deficiency, was known in antiquity and was described in detail by Francis Glisson in 1650. Yet despite this history, the “Sunshine Vitamin” is still heavily investigated and important work continues to be done.

This past year, Life Enhancement reported that:

  • Higher Vitamin D levels support alkali supplementation (certainly as Potassium Bicarbonate) as a promising intervention to promote preservation of skeletal muscle mass. (See the April issue, “Biomedical Updates”)

  • A combination of calcium plus Vitamin D resulted in a 49% reduction in falls as compared to calcium alone. (See the May issue, “Announcing Durk & Sandy’s … New Lithium Formulation”)

  • High Levels of Vitamin D decrease dementia and that includes Alzheimer’s disease. (See the October issue, “High Levels of Vitamin D Decrease Dementia”)

  • Vitamin D helps reduce the risk of most cancers. Cancer patients with high levels of vitamin D (at the point of diagnosis) often have better survival rates and remain in remission longer than patients who are vitamin D-deficient. (See same reference as above)

  • Vitamin D Associated with lower mortality. The risk ratio for the highest versus the lowest quartile of circulating vitamin D levels was 0.55 for overall survival of colorectal cancer patients, 0.63 for breast cancer patients, and 0.48 for lymphoma patients.

  • Higher Vitamin D levels were significantly associated with reduced cancer-specific mortality for patients with colorectal and lymphoma and improved disease-free survival for patients with breast cancer or lymphoma.

  • Vitamin D deficient twice as likely to suffer dementia and Alzheimer’s

  • Risk of dementia increased from 53 – 125 percent in those deficient in Vitamin D

  • Vitamin D for Cytokine Storms. At the same time that vitamin D stimulates expression of genes that create antimicrobial peptides, [vitamin D] is also reported to “dampen certain arms of the adaptive immune system, especially those responsible for the signs and symptoms of acute inflammation, such as the cytokine storms operative when influenza kills quickly.” (See the December 2014 issue, “Foiling Cytokine Storms with Cholinergics” )

  • “Take Vitamin D as a prophylactic. As a nutrient, 4000 IU/day may be an appropriate dose for most adults for health maintenance. If a deadly viral infection arrives in your town, then you can increase your intake of vitamin D to 8000 IU/day. See the section on vitamin D below for more on this powerful immune-modulating nutrient and new evidence of its beneficial effects in retarding age-associated cognitive decline.” (See the December issue, “Surviving Deadly Viral Epidemics”)

  • “[Vitamin D] has also been shown to have immunomodulating effects on many inflammatory conditions, including infections. “Importantly, Vitamin D has been reported in a recent paper to reduce the production of proinflammatory cytokines, which (the authors suggest) “may reduce the risk of cytokine storm in H1N1 [viral] infection.” (See the December issue, “Surviving Deadly Viral Epidemics”)

  • “[In] vitro studies and some clinical studies suggest that Vitamin D plays an important role in reducing inflammation.” (See the December issue, “Surviving Deadly Viral Epidemics”)

  • “1,25(OH)2D, the biologically active form of vitamin D, “dramatically” stimulates genetic expression of antimicrobial peptides (AMP) by human monocytes, neutrophils, and other immune cells.” (See the December issue, “Surviving Deadly Viral Epidemics”)

  • Vitamin D mitigates cognitive decline by modulating the age-related increase in pro-inflammatory state and amyloid burden

In position #6 is Taurine tied with Selenium, Omega-3, and Berberine.

#7 is Melatonin tied with Inulin, Hesperidin, DMAE, and Lithium For these, whichever one’s are of interest to you, please use the search engine at www.life-enhancement.com, the home page. Happy searching!


Will Block is the publisher and editorial director of Life Enhancement magazine.

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