Oral EDTA along with …

The Benefits of Oral
Vitamins/Minerals and
Chelation Therapy …

… establish an important evidence base

By Will Block

T he popularity of chelation therapy has continued over the years among non-conventional doctors, but without much of an evidence base. Consequently, the National Institutes of Health requested a definitive trial, and as a result, the Trial to Assess Chelation Therapy (TACT) was formulated as a 2 x 2 factorial* randomized controlled trial of intravenous ethylenediaminetetraacetic acid (EDTA)-based chelation vs. placebo and high-dose oral multi-vitamins and multi-minerals vs. oral placebo.1

*  1. Active IV chelation infusions + active oral vitamins
 2. Active IV chelation infusions + placebo oral vitamins
 3. Placebo IV chelation infusions + active oral vitamins
 4. Placebo IV chelation infusions + placebo oral vitamins

Reduced Cardiovascular Events

The primary end point was death, reinfarction, stroke, coronary revascularization, or hospitalization for angina. A total of 1708 post-myocardial infarction (MI) patients who were 50 years or older without serious live malfunction were enrolled and received 55,222 infusions of disodium EDTA or placebo.2 Published in the conventional medicine stronghold, The Journal of the American Medical Association (JAMA), follow-up occurred over a median of 55 months. Patients were on evidence-based post-MI medications such as statins. EDTA proved to be safe. EDTA chelation therapy reduced cardiovascular events by 18%.

Then, one year later, a new report examined the same data but restricted itself to an analysis of the factorial groups in patients with diabetes prior to randomization.3

Pre-specified subgroup analysis revealed a robust benefit in patients with diabetes with a 41% reduction in the primary endpoint and a 43% 5-year relative risk reduction in all-cause. Combined with an excellent safety record, these results are impressive.

The JAMA study had found that among stable patients with a history of (MI), use of an intravenous chelation regimen with disodium EDTA, compared with placebo, modestly reduced the risk of adverse cardiovascular outcomes, many of which were revascularization procedures. And it had also shown safety for EDTA use.

Better Results Than the JAMA Study

In the second study, in stable post-MI patients on evidence-based medical therapy, the combination of oral high-dose vitamins and chelation therapy compared with double placebo reduced clinically important cardiovascular events to an extent that was both statistically significant and of potential clinical relevance.

As Richard Fogoros, M.D. writes on his website About Health,4 “Despite efforts to kill it, chelation therapy for heart disease lives on.” And further, “Specifically, the long-awaited randomized, double-blind Trial to Assess Chelation Therapy (TACT) failed to drive a stake through the heart of [chelation] treatment (as it was apparently designed to do). In fact, TACT has given new life to chelation therapy. And if its results have failed to win over the critics of this form of alternative therapy, the TACT study has at least caused them considerable embarrassment and discomfiture.”

Driving another nail into the coffin of conventional smugness, Dr. Fogoros, quotes Robert A. Vogel, MD, a member of the organizing committee for TACT, who bluntly said, “I can tell you that the original intent was to put this form of therapy to bed.”

The combination of oral high-dose
vitamins and chelation therapy
compared with placebo significantly
reduced clinically important
cardiovascular events to an extent
that was of clinical relevance.

Oral Supplementation Too

According to Ward Dean, M.D., Life Enhancement’s Medical Editor: “Oral EDTA may be used in conjunction with the intravenous treatment. I recommend both oral and IV treatments for maximum efficacy. Intravenous EDTA is administered over a short time—30 minutes to 3 hours—once or twice per week. Virtually all of it is excreted via the kidneys within 24 hours. With daily consumption of oral EDTA, fairly low doses are in the blood, but these levels are there every day. Consumption of 1,000 mg of oral EDTA each day, with absorption of about 10%, is like having one additional intravenous treatment spread over a month.” See “Oral Chelation Or IV Chelation To Improve Bone Density” in the November 2014 issue).


  1. Peguero JG, Arenas I, Lamas GA. Chelation therapy and cardiovascular disease: connecting scientific silos to benefit cardiac patients. Trends Cardiovasc Med. 2014 Aug;24(6):232-40.
  2. Lamas GA, Goertz C, Boineau R, et al. Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial. JAMA. 2013;309(12):1241-50.
  3. Lamas GA, Boineau R, Goertz C, et al. EDTA chelation therapy alone and in combination with oral high-dose multivitamins and minerals for coronary disease: The factorial group results of the Trial to Assess Chelation Therapy. Am Heart J. 2014 Jul;168(1):37-44.
  4. Fogoros R. Does Chelation Therapy Deserve Another Look? May 15, 2014. http://heartdisease.about.com/od/othertreatmentsforcad/fl/Does-Chelation-Therapy-Deserve-Another-Look.htm

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