Dealing with Multiple Sclerosis

Dear Dr. Dean,

I’ve recently been diagnosed with Multiple Sclerosis and have decided to combat the early stages with a healthier lifestyle. I’ve been reading about the effects on MS with Vitamin D. I would love to hear your opinions on the subject as well as any other advice you can offer. Thank you for your time.

JOHN, Stamford, CT

Dear John,

You’re right to consider Vitamin D in your regimen for Multiple Sclerosis. Vitamin D suppresses the development of MS in animal models of the disease:1 a large prospective trial showed an association between high 25(OH)D levels during the years preceding disease onset and a decreased risk of MS,2 and a large human trial has shown that supplementation was associated with a 40% reduction in the risk of developing MS.3

Here are a selection of substances that have been successfully used for MS. These can all be combined, and can be used with conventional pharmaceutical approaches, as well.

A treatment regimen for MS that I’ve used for many years with gratifying results is based on an interesting but long out-of-print book, Multiple Sclerosis and How I Live With It. The book was written by Ray O. Bjork, M.D.—a physician who survived for many years on the program described in his book.4 Dr. Bjork relied almost entirely on one or two weekly injections of Vitamin B12, and 25–50 mg of Adenosine Monophosphate. If unable to obtain a prescription for B12 injections, I recommend 2 mg of oral methylcobalamine each day. Injectable (and oral) Adenosine Monophosphate is available from Legere Pharmaceuticals.5



Figure 1. CaAEP acts as a “cell sealer,” and promotes remyelination of the nerve axon, which is the pathognomonic sign of MS.
The renowned German physician, Dr. Hans Nieper, found Calcium Ethanolamine Phosphate (CaAEP) to be essential for the treatment of MS.6 CaAEP acts as a “cell sealer,” and promotes remyelination of the nerve axon, which is the pathognomonic sign of MS (See Fig. 1). He recommended oral doses of 100-200 mg three times daily.

In 2007, a physician in the Department of Neurology at UCLA proposed that acetylcholinesterase inhibitors (AChEIs) may improve myelin integrity, and suggested that AChEIs such as galantamine might be useful in the prevention and treatment of MS and other neurodegenerative diseases.7

Several studies in 1990 reported that DHEA replacement (25–100 mg/day) in MS patients resulted in increased activities of daily living, and relief of the “fatigue syndrome.”7,8

In Italy, thirty six patients (67% female, average age 44) were treated for 3 months with acetyl-L-carnitine (ALC) 1 g twice daily.10 The result was a significant improvement in the debilitating neuromuscular symptoms and fatigue commonly experienced by those suffering from MS.

A study of low dose naltrexone (1–4.5 mg/day) in 60 patients with MS demonstrated a significant improvement in mental health and self-reported quality of life indices.11

Finally, I would use an array of anti-inflammatory herbs such as Turmeric, EGCG and Boswellia.

A problem with trying to evaluate any preventive or therapeutic treatment with MS is the characteristic variability of the illness. Often, a treatment appears to be working, but the improvement usually does not bring one back to their previous state of health, with a chronic “ratcheting down” of the disease. However, in my experience, the “alternative therapies” outlined above, have resulted in superior results to mainstream conventional therapies.

Ward Dean, MD

References

  1. Brown SJ. The role of vitamin D in multiple sclerosis. Ann Pharmacother. 2006 Jun;40(6):1158–61.
  2. Salzer J, Hallmans G, Nystrom M, Stenlund H, Wadell G, Sundstrom P. Vitamin D as a protective factor in multiple sclerosis. Neurology. 2012 Nov 20;79(21):2140–5.
  3. Cantorna MT, Zhao J, Yang L. Vitamin D, invariant natural killer T-cells and experimental autoimmune disease. Proc Nutr Soc. 2012 Feb;71(1):62–6.
  4. Bjork RO. Multiple Sclerosis and How I Live With It. Birchbark Press, Phoenix, 1978.
  5. Legere Pharmaceuticals, 15344 N. 83rd Way, Scottsdale, AZ 85260 (800)–528–3144 Send Mail
  6. Nieper H. Dr. Nieper’s Revolution in Technology, Medicine and Society. MIT Verlag, Oldenburg, 1985.
  7. Bartzokis G. Acetylcholinesterase inhibitors may improve myelin integrity. Biol Psychiatry. 2007;62:294–301.
  8. Roberts E, Faublet TJ. Oral DHEA in MS. Results of a Phase One Open Study, in: The Biological Role of DHEA. Kalami M, Regelson W, editors. Walter de Gruyter, Inc. New York, 1990.
  9. Calabrese VP, Isaacs ER, and Regelson W. Dehydroepiandrosterone inmultiple sclerosis: Positive Effects on the Fatigue Syndrome in a Non-Randomized Study, in: The Biological Role of DHEA. Kalami M, Regelson W, editors. Walter de Gruyter, Inc. New York, 1990.
  10. Tomassini V, Pozzilli C, Onesti E, et al. Comparison of the effects of acetyl-L-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomized, double-blind, crossover trial. J Neuro Sci. 2004;218:103–8.
  11. Cree BA, Kornyeyeva E, Goodin DS. Pilot trial of low-dose naltrexone and quality of life in multiple sclerosis. Ann Neurol. 2010 Aug;68(2):145–50. doi: 10.1002/ana.22006.

In addition, I usually recommend oral supplements of Phosphatidylserine (300 mg per day) and Phosphatidylcholine (2,000–3000 mg per day). Also, N-Acetylcysteine caps (1,800 mg per day). NAC is a precursor of glutathione, a powerful antioxidant.

Phosphatidylserine, phosphatidylcholine, and NAC are all available from any reputable supplement company.

Also see the following abstract:

  • Cree BA, Kornyeyeva E, Goodin DS. Pilot trial of low-dose naltrexone and quality of life in multiple sclerosis. Ann Neurol. 2010 Aug;68(2):145–50. doi: 10.1002/ana.22006.

OBJECTIVE: To evaluate the efficacy of 4.5mg nightly naltrexone on the quality of life of multiple sclerosis (MS) patients.

METHODS: This single-center, double-masked, placebo-controlled, crossover study evaluated the efficacy of 8 weeks of treatment with 4.5mg nightly naltrexone (low-dose naltrexone, LDN) on self-reported quality of life of MS patients.

RESULTS: 60 subjects completed the trial. LDN was well tolerated, and serious adverse events did not occur. LDN was associated with significant improvement on the following mental health quality of life measures: a 3.3-point improvement on the Mental Component Summary score of the Short Form-36 General Health Survey, a 6-point improvement on the Mental Health Inventory, a 1.6-point improvement on the Pain Effects Scale, and a 2.4-point improvement on the Perceived Deficits Questionnaire.

INTERPRETATION: LDN significantly improved mental health quality of life indices.

Comment in: A patient-supported clinical trial. [Ann Neurol. 2010]

Re: Adenosine Monophosphate (Called MY-B-TABS™)

Category: Anti-Aging

Sublingual Adenosine

Product No. 1043

Ingredients: Each flavored sublingual tablet contains —Adenosine (AMP) 25 mg, B12 (Cyanocobalamin) 50 mcg, Folic Acid 10 mcg

For any cell in the body to exist, it must produce its own energy in order to maintain basic metabolic functions such as taking up and utilizing nutrients, synthesizing new proteins, and discarding waste material. In response to systemic cellular energy deficits, the organism first encounters health disorders and will then die. Most of the cellular energy is produced in the form of adenosine triphosphate (ATP) from structures in the cell called mitochondria. Diseases of aging are often referred to as “mitochondrial disorders”: As mitochondrial function weakens in the cells, lowering energy production, so does the vitality of the organs such as the heart and brain.

Adenosine Monophosphate appears to be beneficial for correcting low energy production due to mitochondrial dysfunction. My-B-Tabs provides 25mg Adenosine Monophosphate per tablet in an easy to dissolve sublingual tablet (which may also be chewed). 15344 N. 83rd Way, Scottsdale, AZ 85260. 800.528.3144. For references: Send Mail.

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