The Durk Pearson & Sandy Shaw®
Life Extension NewsTM
Volume 18 No. 5 • September 2015


Unfortunately, both of us have moderate cases of knee osteoarthritis, with Sandy’s knees significantly more painful. We had run out of lycopene and after a few days to a couple of weeks we both noticed more pain in our knees. The day we went back on lycopene (we started on 15 mg. a day, though Sandy has upped hers to 30 mg. a day now that she has felt the difference), we were both aware of much more comfort in walking. The best way to take it is with the fattiest meal of the day, as it is absorbed best with fats.

It is also interesting that lycopene is another one of the natural products that inhibits for formation of inflammatory prostaglandins. See (Shaw, 2015) “Why the Niacin Flush May Be Surprisingly Beneficial to Your Health” by Sandy Shaw for a discussion—in Part I under the subheading “What Is the Flush?”—of inflammation and the prostaglandins that play such a major role in it, particularly PGE2 and PGD2. PGD2 is prostaglandin D2 that is the cause of the niacin flush and which counters the effects of inflammatory PGE2 when released as a pulse, but there are many ways other than taking niacin to interfere with PGE2-induced inflammation. Lycopene is one such effective antiinflammatory nutrient.


  • Shaw (2015) paper, Part I, is found on the Life Enhancement website,, August 2015.
  • Rafi, Yadav, Reyes. Lycopene inhibits LPS-induced proinflammatory mediator inducible nitric oxide synthase in mouse macrophage cells. J Food Sci. 72(1):S69-S74 (2007).

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