Resveratrol Moderates Alzheimer’s Severity

A randomized, placebo-controlled, double-blind, multicenter study has discovered that high doses of resveratrol may be beneficial for fighting Alzheimer’s disease. In the new report, the first study of resveratrol in people with AD, the researchers reported that pharmaceutical-grade resveratrol helped stabilize a form of amyloid-beta levels in the blood and cerebrospinal fluid of those who consumed resveratrol, compared to a placebo group, which saw the same forms of levels decline. Deposition of Aβ in the brain is a pathological hallmark of AD. There are two major isoforms of Aβ: Aβ42 and Aβ40. A decrease in Aβ40 is seen in the blood and cerebrospinal fluid as dementia worsens and Alzheimer’s disease progresses. Stabilization is good. In the same study, daily activities—such as cooking, getting dressed, using a telephone, tasks of everyday life—declined less in the resveratrol group.

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