The Durk Pearson & Sandy Shaw®
Life Extension NewsTM
Volume 18 No. 7 • November 2015

Coffee Components Inhibit Amyloid Formation of Human IAPP in Vitro: May Explain the Inverse Relation Between Coffee Consumption and Type II Diabetes

Significant Inverse Association Between Tea and Type II Diabetes Incidence

Another aspect of the IAPP-type II diabetes link is found in a recent paper (Cheng, 2011) reporting that three major components of coffee, caffeine, caffeic acid, and chlorogenic acid, all inhibited the toxic aggregation of human IAPP in vitro. The protection was greatest for caffeic acid and least for chlorogenic acid. The paper also reports that in other studies EGCG (especially enriched in green tea) can inhibit the fibril formation of human IAPP (EGCG also inhibits the toxic amyloid formation in Alzheimer’s disease) as well as having protective effects on pancreatic beta cells.

A paper (Huxley, 2009) in a recent issue of Archives of Internal Medicine provided a meta-analysis of 18 studies involving00,000 people on the associations between the consumption of coffee and tea on the incidence of type II diabetes, finding an overall reduction in the risk of the disease. (Protection against the cytotoxic effects of IAPP could be one of the mechanisms responsible, but others are likely to be involved.) The beneficial effects of coffee, decaf coffee, or tea was found for those who ingested four cups a day, with the paper (Huxley, 2009) reporting that “every additional cup of coffee consumed in a day was associated with a 7% reduction in the excess risk of diabetes, 0.93 [95% confidence interval, 0.91-0.95] after adjustment for potential confounders.”


  • Cheng et al. Coffee components inhibit amyloid formation of human islet amyloid polypeptide in vitro: possible links between coffee consumption and diabetes mellitus. J Agric Food Chem. 59:13147-55 (2011).
  • Huxley et al. Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus. Arch Intern Med. 169(22):2053-63 (2009).
  • Kim, Cheon, Jeong, Quan, et al. Amyloidogenic peptide oligomer accumulation in autophagy-deficient beta cells induces diabetes. J Clin Invest. 124(8):3311-24 (2014).
  • Rivera et al. Autophagy defends pancreatic beta cells from human islet amyloid polypeptide-induced toxicity. J Clin Invest. 124(8):3489-3500 (2014).
  • Wu and Sun. Vitamin D, vitamin D receptor, and macroautophagy in inflammation and infection. Discov Med. 11(59):325-35 (2011).
  • Yuk, Shin, Lee, et al. Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe. 6:231-43 (2009).
  • Zhang et al. Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A. I 104(48):19023-8 (2007).

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