The Durk Pearson & Sandy Shaw®
Life Extension NewsTM
Volume 18 No. 8 • December 2015

Hydrogen Administered in Hydrogen Rich Saline Improves Memory in a Rat Model of Amyloid beta Induced Alzheimer’s Disease

The researchers of a paper studying the above subject (Li, 2010) wanted to learn whether hydrogen could reduce inflammation and improve cognition in a rat model of Alzheimer’s disease. The 84 rats were divided into three groups: sham operated (icv injection that did not include amyloid beta1-42), amyloid beta 1-42 icv, and amyloid beta 1-42 icv plus hydrogen saline. Hydrogen saline was injected into the third group of rats for 14 days after intracerebroventricular (icv) injection of Amyloid beta1-42. They were tested for inflammatory cytokines IL-6, and TNFalpha and the lipid peroxidation product malondialdehyde (MDA), as well as testing the rats in the (uh oh) Morris Water Maze and open field trial to test for learning and memory function.

The hydrogen-enriched saline significantly improved animal performance in the Morris Water Maze and enhanced LTP (long term potentiation), an important process in learning, in the hippocampus, where LTP is blocked by amyloid beta1-42. The treatment also reduced levels of the inflammatory cytokines and the malondialdehyde, as well as reducing the hyperactive immune response to HNE and GFAP, which was induced by amyloid beta1-42.

So far, the experiments with hydrogen treatment for various medical conditions have used only hydrogen gas or hydrogen in saline or water. Why nobody is using hydrogen generated by the hydrogen producers residing in the gut microbiota for this purpose is not clear. It is possible that the reason is that a test for evaluating how much hydrogen is generated by the microbiota and which then diffuses into the tissues has not yet been developed; it is much simpler to know how much hydrogen the animals were administered when it is done by gas or by water or saline saturated with hydrogen.

Unlike hydrogen administered by gas or in water/saline, the ingestion of fermentable fibers, such as long chain fructooligosaccharide (long chain inulin), which is a particularly good fuel for the hydrogen producers in the gut, is a simple inexpensive way to get hydrogen into your system, PLUS it is not limited to the short time following the breathing of the gas or the drinking of the hydrogen containing liquid for exposure to hydrogen.

We are both enthusiastic users of our hydrogen power supplement. It is a powder that is not miscible in water, but mixes in very well when added to oatmeal, which is one way we use it. You could also add it to smoothies, casseroles, thick soups, etc. It is stable when cooked.

  • Li, Wang, Zhang, et al. Hydrogen-rich saline improves memory function in a rat model of amyloid beta-induced Alzheimer’s disease by reduction of oxidative stress. Brain Res. 1328:152-61 (2010).

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