A model for truthful and non-misleading information 

Omega-3 Fish Oils Promote Cardiovascular Health 

protected by the First Amendment of the U.S. Constitution

"Consumption of omega-3 fatty acids may reduce the risk of coronary heart disease." This statement was one example of a truthful and nonmisleading biomedical health claim presented by Durk Pearson and Sandy Shaw in their landmark win against the FDA this past January. Given the preponderance of evidence favoring omega-3 oils, the U.S. Appellate Court ruled the burden of proof is on the FDA to show that this statement (or other biomedical claims about supplements) is not true. The FDA didn't because they couldn't.

There is an abundance of scientific data supporting the health benefits of omega-3 oils, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and it is now permissible to tell the truth. High consumption of fish oils containing omega-3 fatty acids helps prevent cardiovascular morbidity and mortality.1

In fact, the research is star-studded:

  • The benefits of omega-3 oils have been attributed principally to the anti-atherogenic (counteracting plaque formation) and anti-thrombotic (counteracting clot formation) effects of these oils.2
  • More recent evidence links fish and fish oils to the prevention of malignant ventricular arrhythmias (life-threatening abnormal electrical conductivity in the heart) and sudden cardiac death.3
  • Animal studies show that fish oils can reduce the incidence of ischemia (lack of oxygen) induced ventricular tachycardia and fibrillation (abnormal heart rhythms).4
  • Observational studies in humans demonstrate a connection between the intake of omega-3 fatty acids and a lower risk of sudden cardiac death.5
  • Some trials suggest that fish oils can prevent ventricular arrhythmias in humans.6
  • It is possible that the effect of fish oils on arrhythmias is independent of their anti-atherogenic and anti-thrombotic activities.7
  • There is also some evidence that these oils affect ion fluxes in cardiomyocytes (muscle cell of the heart).8
  • Fish oils influence membrane stability, membrane fluidity, cell mobility, the formation of receptors, binding of ligands (small molecules) to their receptors, and the activation of intracellular signaling pathways directly or through the formation of eicosanoids, gene expression, and cell differentiation.9
  • Other evidence suggests that fish oils may help protect the kidneys, improve rheumatoid arthritis, abate inflammatory bowel diseases, reduce episodes of transplant rejection, and even provide protection from infection.10

Unfortunately, most people are not even eating fresh coldwater fish at least once per week when twice per week is preferable. Therefore, they will not gain the benefits touted in the studies. But there is a surefire way to provide the basic omega-3 oils: taking a well-designed formulation of EPA and DHA plus added Vitamin E and ascorbyl palmitate (fat soluble Vitamin C) to help protect against lipid oxidation and to maintain freshness.

With exceptional research and accomplishments in tocopherol (Vitamin E), ascorbic acid (Vitamin C) development and now omega-3 oils, you can expect the best. And what's more, omega 3-oil supplements cost far less than you'd pay for an equivalent amount of fresh fish!
 

References

  1. Landmark K. Fish, fish oils, arrhythmias and sudden death. Tidsskr Nor Laegeforen 1998 Jun 10;118(15):2328-2331.
  2. Sorrentino M, Marini D, Troiani A, Pantaleoni GC Polyunsaturated fatty acids and atherosclerosis. Boll Chim Farm. 1991 Sep;130(8):297-31.
  3. Landmark, Ibid.
  4. Landmark, Ibid.
  5. Leaf A, Kang JX. Prevention of cardiac sudden death by N-3 fatty acids: a review of the evidence. J Intern Med. 1996 Jul;240(1):5-12.
  6. Ibid.
  7. Kang JX, Leaf A. Prevention and termination of beta-adrenergic agonist-induced arrhythmias by free polyunsaturated fatty acids in neonatal rat cardiac myocytes. Biochem Biophys Res Commun. 1995 Mar 17;208(2):629-36.
  8. Delerive P, Oudot F, Ponsard B, Talpin S, Sergiel JP, Cordelet C, Athias P, Grynberg A. Hypoxia-reoxygenation and polyunsaturated fatty acids modulate adrenergic functions in cultured cardiomyocytes. J Mol Cell Cardiol. 1999 Feb;31(2):377-86.
  9. Alexander JW. Immunonutrition: the role of omega-3 fatty acids. Nutrition 1998 Jul-Aug;14(7-8):627-33.
  10. Ibid.
© Copyright 1999 Life Enhancement Products, Inc. All Rights Reserved.

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