The Durk Pearson & Sandy Shaw®
Life Extension NewsTM
Volume 18 No. 4 • January 2016


Chen et al. Activation of TRPV1 channel by dietary capsaicin improves visceral fat remodeling through connexin43-mediated Ca2+ influx. Cardiovasc Diabetol.14:22 (2015).

The above paper discusses the stimulation by capsaicin (hot pepper) of the burning of fat by adipocytes in visceral fat. Niacin, a TRPV1 agonist, signals brown fat and other types of cells to use fat as a fuel rather than glucose, though we do not have a reference at hand that niacin signals such a switch in fuel use in adipocytes in the heart nor do we know whether capsaicin does that in the heart. This could be important as the heart is highly dependent on fat burning for the production of energy. See Virtue et al. A new role for lipocalin prostaglandin D synthase in the regulation of brown adipose tissue substrate utilization. Diabetes. 61:3139-47 (2012). Prostaglandin D synthase is activated by niacin during the niacin flush. For more, see Sandy Shaw’s niacin flush paper in the August, September, and October Life Enhancement website. Li et al. TRPV1 activation impedes foam cell formation by inducing autophagy in oxLDL-treated smooth muscle cells. Cell Death Dis. 5:e1182 (2014).

Foam cells are a major part of the atherosclerotic process. Here, the researchers used smooth muscle cells derived from mice. Capsaicin was used to activate TRPV1.

Suggestion: Take capsaicin capsules as a daily supplement

VITAMIN D3 promotes the recovery of amyloid beta clearance by phagocytes in ALZHEIMER’S DISEASE macrophages derived from human patients.


  • Mizwicki et al. Genomic and nongenomic signaling induced by 1alpha,25(OH)2-vitamin D3 promotes the recovery of amyloid-beta phagocytosis by Alzheimer’s disease macrophages. J Alzheimer’s Dis. 29(1):51-62 (2012).

DAYDREAMS: NOREPINEPHRINE facilitates what is called “task unrelated thoughts” or (more commonly) daydreams.


  • Smallwood et al. Insulation for daydreams: a role for tonic norepinephrine in the facilitation of internally guided thought. PLoS ONE. 7(4):e33706 (2012).

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