The Durk Pearson & Sandy Shaw®
Life Extension NewsTM
Volume 19 No. 6 • July 2016


DOPAMINE IS RELEASED IN RESPONSE TO HIGHLY PALATABLE FOOD
WHY IS THIS RELEASE ATTENUATED FOLLOWING REPEATED SERVINGS?

Many papers (see, for example, Avena, 2011) report that the release of dopamine that normally accompanies the consumption of a tasty meal becomes attenuated as the meal progresses, suggesting (according to some papers) that this is due to a loss of “novelty” of the food. We wonder whether this is the reason for decreasing pleasure in a meal and suggest that it might be due, instead, to a downregulation of the dopaminergic receptors or transient exhaustion of the dopamine supply.

Reference

Avena et al. Overlaps in the nosology of substance abuse and overeating: the translational implications of ‘food addiction’. CURRENT DRUG ABUSE REVIEWS 4:133-139 (2011)

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