The Durk Pearson & Sandy Shaw®
Life Extension NewsTM
Volume 19 No. 6 • July 2016


KETONES ARE FUEL FOR THE EYE’S PHOTORECEPTORS

POSSIBLY PROTECTIVE AGAINST MACULAR DEGENERATION

Other tissues, besides those of the brain, use ketones as a source of energy when glucose is in short supply. The retina, for example, is highly energetic, requires (like the rest of the brain) a continuously available energy source and can also use ketones as a replacement when there is an inadequate supply of glucose. “... the retina uses not only glucose, but also fatty acids, as an energy source, and [ ] the beta-oxidation of fatty acids has an important role in meeting the demands of photoreceptors. Thus defective fatty acid metabolism could contribute to the development of AMD [age-related macular degeneration].” (Rajala, 2016)

References

Rajala and Gardner. Burning fat fuels photoreceptors. Nat Med. 6;22(4):342-3. doi: 10.1038/nm.4080. (2015); Joyal et al. Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar 1. Nat Med. 22(4):439-45 (2016).

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