EDTA Chelation for ED

Figure 1 Ethylenediamine tetraacetic acid (EDTA) chelates calcium and several other metal ions. Calcium is necessary for a wide range of enzyme reactions of the coagulation cascade, and its removal irreversibly prevents blood clotting. Historically, EDTA has been recommended as the anticoagulant of choice for hematological testing because it allows the best preservation of cellular components and morphology of blood cells. Banfi G, Salvagno GL, Lippi G. The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes. Clin Chem Lab Med. 2007;45(5):565-76.
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I am on aspirin to thin my blood, and rosuvastatin calcium 10 mg to lower my cholesterol. Can I now come off of these two drugs?

After reading the information on the Life Enhancement website, it appears that this product should be good for ED (erectile dysfunction), but I didn’t see anything that specifically addressed chelation as a remedy for ED.

CHARLES, Nova Scotia, Canada

Hi, Charles,

Sorry for taking so long to get back to you.

With regard to your first question, I believe you should continue to take aspirin, as you have been doing. I am a big believer in the multiple benefits of aspirin. Although aspirin is popularly used for its anti-coagulant/platelet aggregation-inhibiting properties to prevent blood clots, which can result in heart attacks and strokes, it is also an effective anti-inflammatory agent.

Ethylenediamine tetraacetic acid (EDTA), the active ingredient in the EDTA Chelator Complex is also an effective anti-coagulant, but acts by a different mechanism. EDTA chelates calcium and several other metal ions. Calcium is necessary for a wide range of enzyme reactions of the coagulation cascade, and its removal irreversibly prevents blood clotting. Historically, EDTA has been recommended as the anticoagulant of choice for hematological testing because it allows the best preservation of cellular components and morphology of blood cells.1

Figure 2 NO pathway showing citrulline
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However, I strongly recommend that you discontinue rosuvastatin, or any statin (including red yeast rice extract). I think statins are BAD DRUGS, and should rarely, if ever, be used. A recent review provided significant evidence that statins contribute to atherosclerosis and congestive heart failure.2 The most common side effects from statins are weakness and damage to muscles; and the muscle that works 24 hours/day is our heart! Of particular interest to you may be the growing number of reports indicating that Simvastatin and other statins may be a cause of ED.3-5

If your cholesterol and other lipids are out of range, I believe that Niacin (as in LE’s Niacin Easy) is the lipid-lowering agent of choice. Niacin lowers total cholesterol, LDL, and especially triglycerides, and raises HDL (Fig. 1).6 It has the perfect effect on the lipid profile. Doses of 1,000-2000 mg per day are usually quite effective, although doses as high as 6,000 mg per day have been used. Phosphatidylcholine has a similar, but not quite so pronounced effect.

Since chelation therapy improves blood flow systemically, it will also have an indirectly beneficial effect on ED. Another supplement that has a more direct effect is Citrulline. Oral citrulline has been shown to improve erection hardness in patients with mild ED.7 In this study, 24 men with mild ED [erection hardness score (EHS) of 3] received a placebo for 1 month, followed by citrulline, at 1.5 g/day split into two doses, for another month. At the end of the study, 12 (50%) of the 24 men reported achieving an EHS of 4 (an EHS of 3 is considered “hard enough for penetration but not completely hard,” while an EHS 4 is “completely hard and fully rigid”). Thus, citrulline increased hardness by 50%. In addition, citrulline increased successful intercourse connects by 56% more than placebo, and all patients whose EHS improved from 3 to 4 reported being “very satisfied.” Life Enhancement’s Inner Power contains 500 mg of citrulline per serving (see Fig. 2).

Ward Dean, MD

References

  1. Banfi G, Salvagno GL, Lippi G. The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes. Clin Chem Lab Med. 2007;45(5):565-76.
  2. Okuyama H, Langsjoen PH, Hamazaki T, Ogushi Y, Hama R, Kobayashi T, & Uchino H, (2015) Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms, Expert Review of Clinical Pharmacology, 8:2, 189-199.
  3. Solomon H, Samarasinghe YP, Feher MD, Man J, Rivas-Toro H, Lumb PJ, Wierzbicki AS, Jackson G. Erectile dysfunction and statin treatment in high cardiovascular risk patients. Int J Clin Pract. 2006 Feb;60(2):141-5.
  4. Rizvi K, Hampson JP, Harvey JN. Do lipid-lowering drugs cause erectile dysfunction? A systematic review. Fam Pract. 2002 Feb;19(1):95-8.
  5. La Vignera S, Condorelli RA, Vicari E, Calogero AE. Statins and erectile dysfunction: a critical summary of current evidence. J Androl. 2012 Jul-Aug;33(4):552-8.
  6. Klimov AN, Konstantinov VO, Lipovetsky BM, et al. “Essential” phospholipids versus nicotinic acid in the treatment of patients with type IIb hyperlipoproteinemia and ischemic heart disease. Cardiovasc Drugs Ther. 1995;9:779-784.
  7. Cormio L, De Siati M, Lorusso F, Selvaggio O, Mirabella L, Sanguedolce F, Carrieri G. Oral citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Urology. 2011 Jan;77(1):119-22.

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